Results 31 to 40 of about 4,933 (214)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modeling leakage current of ceramic insulators subject to high pollution levels for improving maintenance activities

Dyna, 2018
This paper presents a useful model to determine the washing periods and to indicate the pollution levels of electrical insulators. The behavior of leakage current, which is one indicator of the presence of pollutants on the insulator surfaces, was ...
Rafael Castillo-Sierra, Oscar Oviedo-Trespalacios, John E. Candelo, Jose Daniel Soto-Ortíz   +3 more
doaj   +1 more source

Study Of Measurements Leakage Current In Oil Transformer

Diyala Journal of Engineering Sciences, 2020
The oil transformer is used in (H.V ) ment's to avoid the electrical breakdown , and heat effect ,so that the oil using as an insulation  and cooling in electrical  instruments to prevent the failure in the transformer. In our research  the measurements
Hassan J. Mohammed
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analysis and modeling of leakage current sensor under pulsating direct current

AIP Advances, 2017
In this paper, the transformation characteristics of current sensor under pulsating DC leakage current is investigated. The mathematical model of current sensor is proposed to accurately describe the secondary side current and excitation current.
Kui Li, Yihua Dai, Yao Wang, Feng Niu, Zhao Chen, Shaopo Huang   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Intelligent electric control system design for mine horizontal directional drilling rig

Gong-kuang zidonghua, 2021
In order to solve the problems of low degree of intelligence, single function and poor safety of electric control system of domestic horizontal directional drilling rigs, an intelligent electric control system for mine horizontal directional drilling rig
LIU Zhu1, LI Linbo2, DU Jianrong2, ZHANG Yuxiang1, SONG Jiancheng1   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Analysis of Grading Ring Design Parameters and Heat Sink Numbers Effect on Voltage Distribution and Leakage Current in Metal Oxide Surge Arrester

Iranian Journal of Electrical and Electronic Engineering, 2014
Metal oxide surge arresters (ZNO) are used widely in power system to protect equipments from over voltages. Non uniform potential distribution leads to the depressed service life and low safe reliability, so grading ring is applied on HV surge arrester ...
M. Khodsuz, M. Mirzaie
doaj  

Single phase transformerless inverter for grid connected photovoltaic system with reduced leakage current

Electrical engineering & Electromechanics, 2022
Introduction. Transformerless inverters are of vital importance in the field of grid connected solar photovoltaic systems offering higher efficiency than the conventional one. i.e., using transformer.
G. Janardhan, N. N. V. Surendra Babu, G. N. Srinivas   +2 more
doaj   +1 more source