Results 31 to 40 of about 233,529 (263)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Dyna, 2018 This paper presents a useful model to determine the washing periods and to indicate the pollution levels of electrical insulators. The behavior of leakage current, which is one indicator of the presence of pollutants on the insulator surfaces, was ...
Rafael Castillo-Sierra +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Energies, 2020 Recently, eco-friendly energy conversion policies have been being promoted through de-nuclearization and de-coal. For this purpose, a super grid should be built to optimize sustainable renewable energy resources such as solar and wind power. Accordingly,
Heon-Gyeong Lee, Jin-Gyu Kim
doaj +1 more source
Study on surface leakage current at sidewall in InP-based avalanche photodiodes with mesa structure
AIP Advances, 2022 A multi-mesa InGaAs/InP avalanche photodiode (APD) with the advantage of the completely restricted electric field is proposed. The surface defects, which are the reasons for the sidewall leakage current generation in the mesa-structure APD, are ...
Junqin Zhang +3 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Iranian Journal of Electrical and Electronic Engineering, 2014 Metal oxide surge arresters (ZNO) are used widely in power system to protect equipments from over voltages. Non uniform potential distribution leads to the depressed service life and low safe reliability, so grading ring is applied on HV surge arrester ...
M. Khodsuz, M. Mirzaie
doaj
Analysis and modeling of leakage current sensor under pulsating direct current
AIP Advances, 2017 In this paper, the transformation characteristics of current sensor under pulsating DC leakage current is investigated. The mathematical model of current sensor is proposed to accurately describe the secondary side current and excitation current.
Kui Li +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source