Results 1 to 10 of about 31,360 (132)

Gut Microbiota, Leaky Gut, and Autoimmune Diseases [PDF]

Frontiers in Immunology, 2022
With the rising prevalence of autoimmune diseases, the role of the environment, specifically the gut microbiota, in disease development has grown to be a major area of study.
Anna Christovich, Xin M. Luo
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Live probiotic bacteria administered in a pathomimetic Leaky Gut Chip ameliorate impaired epithelial barrier and mucosal inflammation [PDF]

Scientific Reports, 2022
Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial permeability and intestinal inflammation to assess probiotic intervention as live biotherapeutics.
Soyoun Min, Nam Than, Yong Cheol Shin, Grace Hu, Woojung Shin, Yoko M. Ambrosini, Hyun Jung Kim   +6 more
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Severity of atopic dermatitis is associated with gut-derived metabolites and leaky gut-related biomarkers [PDF]

Scientific Reports
Dysbiosis of the gut microbiota may contribute to metabolic dysregulation, intestinal barrier disruption, and inflammatory disorders. The objective was to identify gut-derived metabolites and leaky gut biomarkers linked to atopic dermatitis.
Leszek Blicharz, Emilia Samborowska, Radosław Zagożdżon, Iwona Bukowska-Ośko, Joanna Czuwara, Michał Zych, Aleksander Roszczyk, Karol Perlejewski, Karolina Makowska, Joanna Nowaczyk, Michał Zaremba, Karolina Kazimierska, Anna Waśkiel-Burnat, Michał Dadlez, Zbigniew Samochocki, Małgorzata Olszewska, Marek Radkowski, Lidia Rudnicka   +17 more
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Lactiplantibacillus plantarum 22 A-3 ameliorates leaky gut in mice through its anti-inflammatory effects [PDF]

Scientific Reports
There are limited studies on the improvement of leaky gut with minor inflammation associated with various diseases. To explore the therapeutic potential of Lactiplantibacillus plantarum 22 A-3, a member of the Lactobacillus species, in addressing a leaky
Takashi Kobayashi, Takaomi Kessoku, Michihiro Iwaki, Asako Nogami, Masato Yoneda, Satoru Saito, Yoshie Yamana, Yosuke Nishitani, Hiroshige Kuwahara, Atsushi Nakajima   +9 more
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Differential Effects of Nonsteroidal Anti-Inflammatory Drugs in an In Vitro Model of Human Leaky Gut [PDF]

Cells, 2023
The intestinal barrier is the main contributor to gut homeostasis. Perturbations of the intestinal epithelium or supporting factors can lead to the development of intestinal hyperpermeability, termed “leaky gut”.
Michele d’Angelo, Laura Brandolini, Mariano Catanesi, Vanessa Castelli, Cristina Giorgio, Margherita Alfonsetti, Mara Tomassetti, Mara Zippoli, Elisabetta Benedetti, Maria Candida Cesta, Sandro Colagioia, Pasquale Cocchiaro, Annamaria Cimini, Marcello Allegretti   +13 more
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Leaky Gut and the Ingredients That Help Treat It: A Review [PDF]

Molecules, 2023
The human body is in daily contact with potentially toxic and infectious substances in the gastrointestinal tract (GIT). The GIT has the most significant load of antigens. The GIT can protect the intestinal integrity by allowing the passage of beneficial
Ricardo Santos Aleman, Marvin Moncada, Kayanush J. Aryana   +2 more
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Effects of Limosilactobacillus reuteri strains PTA-126787 and PTA-126788 on intestinal barrier integrity and immune homeostasis in an alcohol-induced leaky gut model [PDF]

Scientific Reports
Intestinal barrier is a first line of defense that prevents entry of various harmful substances from the lumen into the systemic environment. Impaired barrier function with consequent translocation of harmful substances into systemic circulation (“leaky ...
Dharanesh Gangaiah, Min Gu, Aline Zaparte, Olaf Will, Laurie C. Dolan, Anthony Goering, Jason Pillai, Shrinivasrao P. Mane, German Plata, Emily B. Helmes, David A. Welsh, Arvind Kumar Mahajan   +11 more
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Identification of leaky gut-related markers as indicators of metabolic health in Dutch adults: The Nutrition Questionnaires plus (NQplus) study.

PLoS ONE, 2021
Background and aimChronic inflammation is a primary risk factor for chronic metabolic disease and may be triggered by a "leaky gut." Several biomarkers have been recognized to indicate intestinal permeability (i.e., leaky gut) and bacterial translocation.
Hiroyuki Hoshiko, Edith J M Feskens, Els Oosterink, Renata M C Ariens, Jurriaan J Mes, Nicole J W de Wit   +5 more
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Intestinal Alkaline Phosphatase Prevents Sulfate Reducing Bacteria-Induced Increased Tight Junction Permeability by Inhibiting Snail Pathway

Frontiers in Cellular and Infection Microbiology, 2022
Tight junctions (TJs) are essential components of intestinal barrier integrity and protect the epithelium against passive paracellular flux and microbial translocation.
Sudha B. Singh, Cristina N. Coffman, Matthew G. Varga, Amanda Carroll-Portillo, Cody A. Braun, Henry C. Lin, Henry C. Lin   +6 more
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Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression

BMC Psychiatry, 2022
Background The pathophysiological mechanisms of aggression are manifold and they may closely interconnect. Current study aimed to determine the gut microbiota and its metabolites, and clarify their correlations with inflammation, oxidation, leaky gut and
Hongxin Deng, Lei He, Chong Wang, Teng Zhang, Hua Guo, Hongwei Zhang, Yanning Song, Bangtao Chen   +7 more
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