Results 121 to 130 of about 111,920 (305)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Soft investment: lean versus traditional plants
Lean production comprises a set of different tools geared towards the elimination of all operations that do not add value to a product, service or process, thereby increasing the value of each activity and removing all that is not required.
Peacock, Tim +4 more
core
TOPICAL ISSUES OF QUALITY MANAGEMENT IN HEALTH CARE
Russian Journal of Economics and Law, 2013 Objective: to propose optimal variants of solving the key issues health care of reforming while researching the level of the medical services consumers’ satisfaction taking into account the opinions of the sector’s personnel.
G. R. Khamidullina
doaj
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Evaluating lean in healthcare [PDF]
The overarching aim of this thesis is to evaluate Lean implementation in the English NHS. Against a background of financial austerity measures and the ostensible widespread adoption of Lean in the UK public sector, and particularly by healthcare ...
Burgess, Nicola
core
Implementation of lean manufacturing process to XYZ Company in Minneapolis area [PDF]
, 2004 Plan BToday, numerous companies have a major opportunity to reduce their costs and customer lead time and cycle time through the application of Lean Manufacturing processes.
Yamashita, Kazuhiro
core
Lean strategy in SMEs: Inventory leanness, operational leanness, and financial performance
Asian Journal of Shipping and LogisticsLean strategy, aimed at optimizing resources, minimizing energy usage, and achieving zero waste in the production process, has been increasingly embraced to reduce systemwide costs in manufacturing.
Feng Liu +5 more
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Exploration of the integration of Lean and environmental improvement [PDF]
, 2009 With increasing awareness of the environmental damage that is occurring as a result of human activities, there are also increasing pressures on manufacturing companies to reduce environmental impacts.
Biggs, Claire
core