Results 101 to 110 of about 6,262,714 (282)

Lean manufacturing implementation in reducing waste for electronic assembly line

MATEC Web of Conferences, 2017
Lean manufacturing is the most convenient way to eliminate unnecessary waste and can provide what customers demand. This paper presents possibilities and sustainability of application of lean manufacturing method by using a virtual simulation of the ...
Zakaria Nurul Husna, Nik Mohamed Nik Mohd Zuki, Ab Rahid Mohd Fadzil Faisae, Mohd Rose Ahmad Nasser   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Simulation Modelling for Lean Production: Case Study

, 2018
This article presents the simulation results of using Arena software in investigating the influence of lean production that depend on sequencing techniques in a manufacturing firm which operates based on engineer-to-order.
Wan Mahmood, W.H., Ab Rahman, M.N., Muhamad, M.R., Salleh, M.R., Yusup, M.Z.   +4 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Lean Production und Produktionsplanung - ein Widerspruch?

, 2022
29 FolienDer Beitrag schildert anfangs das unterschiedliche Grundverständnis der Ansätze Lean Production versus klassische PPS. Im weiteren wird ein Produktionssystem für Klein- und Mittelständische Unternehmen, welches die Elemente des Lean Production ...
Lickefett, Michael, Erlach, Klaus
core   +1 more source

Towards Principles for Designing Lean Intralogistics Systems: Systematic Transfer of Lean Thinking to Reduce Waste in Intralogistics

Proceedings of the Conference on Production Systems and Logistics
In lean production, the five well-known design principles of value specification, value stream orientation, flow, pull, and pursuit of perfection have proven successful [1].
Langenfeld, Lena, Bauernhansl, Thomas, Herberger, David, Hübner, Marco   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Modification of the Tribomechanical Cutting Regime in Longitudinal-Torsional Ultrasonic Milling: From Adhesion to Controlled Fragmentation

Eng
Machining Nomex honeycomb structures presents a major challenge due to their thin-walled architecture, orthotropic behavior, and sensitivity to adhesion and delamination.
Oussama Beldi, Tarik Zarrouk, Ahmed Abbadi, Mohammed Nouari, Wenfeng Ding, Mohammed Abbadi, Jamal-Eddine Salhi, Mohammed Barboucha   +7 more
doaj   +1 more source