Results 91 to 100 of about 111,920 (305)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Lean Supply Chain Management: a lean approach applied to distribution – a literature review of the concepts, challenges and trends [PDF]

, 2020
Developed between 1948 and 1975, the Toyota Production System (TPS) has in its essence increasing profitability through the elimination of losses. The TPS continued to evolve, becoming better known as just-in-time (JIT) production and, in the sequence ...
Alvim, Silvio Luiz, Oliveira, Ottomar Galizio   +1 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Comparing production design activities and location-based planning tools

, 2017
What are the differences between production system design and work structuring? And between phase scheduling and work structuring? Which lean planning tool is better suited for each one of these design processes: line of balance, takt-time planning or ...
Kagioglou, Mike (R20008), Koskela, Lauri, Clarissa Biotto, Biotto, Clarissa, Tzortzopoulos, Patricia, Patricia Tzortzopoulos, Mike Kagioglou, Kagioglou, Mike, Lauri Koskela   +8 more
core   +1 more source

Barriers for lean healthcare implementation: a systematic literature review [PDF]

, 2022
The literature has shown that some barriers can hinder the implementation of lean healthcare, negatively impacting the sustainability of this production system.
de Medeiros, Eveliny Dias, Santos, Luciano Costa, Gohr, Cláudia Fabiana   +2 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

SimLean : utilising simulation in the implementation of lean in healthcare [PDF]

, 2012
Discrete-event simulation (DES) and lean are approaches that have a similar motivation: improvement of processes and service delivery. Both are being used to help improve the delivery of healthcare, but rarely are they used together.
Worthington, Claire, Radnor, Zoe J., Robinson, Stewart, Burgess, N., Worthington, C., Zoe Radnor (1251978), Robinson, S., Burgess, Nicola, Stewart Robinson (1258410), Radnor, Z. J., Claire Worthington (7200104), Radnor, Z., Nicola Burgess (7200101), Radnor, Zoe Jane   +13 more
core   +1 more source

Data Science Supporting Lean Production: Evidence from Manufacturing Companies

Systems
Research in lean production has recently focused on linking lean production to Industry 4.0 by discussing the positive relationship between them. In the context of Industry 4.0, data science plays a fundamental role, and operations management research is
Rossella Pozzi, Violetta Giada Cannas, Tommaso Rossi   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source