Results 71 to 80 of about 111,920 (305)

Lean construction: Prospects for the German construction industry

open access: yes, 2007
There is little, if any, information available about the range and dissemination of lean concepts among construction companies in Germany. Building on the methodologies and conceptual frameworks used in earlier work in the UK (Common et al., 2000) and ...
Walter, Lorenz, Johansen, Eric
core  

Konsequenzen der Lean Production für den Logistik-Bereich

open access: yes, 2022
16 S.Der Beitrag macht deutlich, daß die unter den Schlagwörtern "Lean Production" und "Simultaneous Engineering" publizierten Methoden und Ansätze durchaus nicht neu sind. Vielmehr ist das Gedankengut schon seit längerem bekannt. Die "härter" gewordenen
Beckmann, H., Harland, J., Kuhn, A.
core  

MES Support for Lean Production [PDF]

open access: yes, 2013
In the traditional sense, IT has often been viewed as a contributor to waste within lean production. However, as the business world changes and competition from low-cost countries increases, new models must be developed which deliver competitive advantage by combining contemporary technological advances with the lean paradigm.
Daryl Powell   +2 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Addressing information flow in lean production management and control in construction

open access: yes, 2014
Traditionally, production control on construction sites has been a challenging area, where the ad-hoc production control methods foster uncertainty - one of the biggest enemies of efficiency and smooth production flow.
Kubler, Silvain   +3 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

A lean framework for tooling design process in Chinese aerospace [PDF]

open access: yes, 2012
Lean Manufacturing (LM) has been used in production processes to help manufacturing companies maintain competitive advantages for decades. However, with the increasingly fierce competition and pressure to sustain survival and long-term growth ...
Yang, Yafang
core  

FEATURES OF IMPLEMENTING LEAN PRODUCTION IN SOCIAL ESTABLISHMENTS

open access: yesRussian Journal of Economics and Law, 2014
Objective: to disseminate ideas and principles of implementing the methodology of lean production. Methods: practical approaches to implementing the tools of lean production in social establishments.
I. I. Antonova   +2 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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