Results 61 to 70 of about 6,262,714 (282)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Intelligent Products: Shifting the Production Control Logic in Construction (With Lean and BIM) [PDF]

, 2015
Production management and control in construction has not been addressed/updated ever since the introduction of Critical Path Method and the Last Planner® system.
Holmström, Jan, Kubler, Silvain, Pikas, Ergo, Koskela, Lauri, Peltokorp, Antti, Dave, Bhargav, Främling, Kary, Singh, Vishal   +7 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Lean management methods: Evidence from the manufacturing industry in the Czech Republic [PDF]

Problems and Perspectives in Management
Lean management is a way to satisfy the increasing customer demands while maintaining production efficiency. This paper aims to map and analyze the level of use of lean management methods in the manufacturing industry in the Czech Republic.
Romana Heinzova, Eva Hoke, Nikola Janova
doaj   +1 more source

ERP Support for Lean Production [PDF]

, 2012
In the traditional sense, IT has often been viewed as a contributor to waste within lean production. However, as the business world changes and competition from low-cost countries increases, new models must be developed which deliver competitive advantage by combining contemporary technological advances with the lean paradigm.
Daryl Powell, Erlend Alfnes, Jan Ola Strandhagen, Heidi C. Dreyer   +3 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Implementing lean: UK culture and systems change [PDF]

, 2004
For the IGLC 12 Conference the authors reported the results of implementing Last PlannerTM methods with a large UK contracting company. The projects studied demonstrated some success but also some cultural, organizational and systemic barriers to its ...
Greenwood, David, Porter, Geoff, Johansen, Eric   +2 more
core  

Directions for improving the key business processes of an electric gird organization by adapting the concept of lean production

Вестник Северо-Кавказского федерального университета
Introduction. The study analyzes the results of the economic activities of Rosseti Group, the functions of the divisions of the executive office of Rosseti Center PJSC within the framework of the implementation of the concept of lean production.
A. V. Shibiko
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source