Results 81 to 90 of about 530,707 (357)

Where Rhetoric and Lean Meet [PDF]

open access: yes, 2015
This paper aims at an initial analysis and explanation of lean through the lens of the discipline of rhetoric. First, the ancient origin, central ideas, subsequent history and current interpretations of rhetoric are outlined.
Koskela, Lauri
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

An exploration of knowledge and understanding – the eighth flow [PDF]

open access: yes, 2013
The argument for understanding Lean construction as a socio-technical field is growing and the need to better consider the role of human beings within construction systems is becoming the dominant factor in project success.
Court, P, Pasquire, C
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Three Models of Adjudicative Representation [PDF]

open access: yes, 2014
Byggindustrin har länge tampats med en undermålig produktivitetsutveckling i förhållande till andra industrier och då speciellt processindustrin. Det har gjorts många försök att industrialisera byggandet för att dra nytta av standardiserade produkter och
ATTERSTRÖM, VICTOR, THEORIN, HENRIC
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

FEATURES OF IMPLEMENTING LEAN PRODUCTION IN SOCIAL ESTABLISHMENTS

open access: yesRussian Journal of Economics and Law, 2014
Objective: to disseminate ideas and principles of implementing the methodology of lean production. Methods: practical approaches to implementing the tools of lean production in social establishments.
I. I. Antonova   +2 more
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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