Results 81 to 90 of about 111,920 (305)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Lean production associated with computer simulation: a systematic review in the healthcare [PDF]
, 2021 Lean manufacturing is currently one of the most widely used philosophies in the world. Prior to Lean, simulation emerged as an extremely powerful tool for analysis, comparison and learning.
Ramos, Edson Carvalho +2 more
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Modello giapponese, toyotismo, produzione snella: alcune questioni aperte
Quaderni di Sociologia, 1992 The paper argues that a distinction should be drawn between the Japanese Model and Lean Production. The first refers to the sum of social and cultural aspects of the Japanese traditional way of managing human resourses, whereas the second refers to the ...
Giuseppe Bonazzi
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Implementing lean: UK culture and systems change
, 2004 For the IGLC 12 Conference the authors reported the results of implementing Last PlannerTM methods with a large UK contracting company. The projects studied demonstrated some success but also some cultural, organizational and systemic barriers to its ...
Greenwood, David +2 more
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Lean Production und Produktionsplanung - ein Widerspruch?
, 2022 29 FolienDer Beitrag schildert anfangs das unterschiedliche Grundverständnis der Ansätze Lean Production versus klassische PPS. Im weiteren wird ein Produktionssystem für Klein- und Mittelständische Unternehmen, welches die Elemente des Lean Production ...
Lickefett, Michael, Erlach, Klaus
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Possibilities of visualization as a lean method in the management of medical organizations
Медицинский вестник Юга России, 2019 The article presents the results of a review of literature on the possibility of visualization in the health care system of the Russian Federation as one of the main methods of implementation of lean production.
Albert A. Kurmangulov +4 more
doaj +1 more source
Advances in Civil Engineering, 2020 Component factories are experiencing the problems associated with lean production, especially the accuracy of production time prediction and the unnecessary waste in terms of time and resource utilization.
Zhenmin Yuan +5 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Model of Lean Supplier Management Based on the Lean Production [PDF]
, 2007 In this paper, we present a model of lean supplier management between an OEM and its suppliers for the objectives of eliminating wastes, reducing cost and improvement continuously based on the lean production. This model includes supplier selection and categorization, supplier improvement, supplier certification and supplier evaluation.
Yixun Guo, Zhiduan Xu
openaire +1 more source