Results 51 to 60 of about 4,771,009 (283)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Integration of Lean and Socio-technical Practices in Sweden

Annals of Business Administrative Science, 2014
Though lean production has its origin in the Toyota Production System (TPS), it has become popular across various industries. During this process, a striking situation has occurred in Sweden, particularly in its service industry.
Ryusuke KOSUGE
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Lean Service Waste Classification and Methodological Application in a Case Study

Journal of Manufacturing and Materials Processing
This study explores the application of Lean principles in the service sector, addressing the complexities of translating manufacturing-focused methodologies to intangible service activities.
Giuseppe Converso, Guido Guizzi, Emma Salatiello, Silvestro Vespoli   +3 more
doaj   +1 more source

IMPLEMENTASI LEAN HEALTHCARE UNTUK MENGIDENTIFIKASI DAN MEMINIMASI WASTE DI INSTALASI RAWAT JALAN RSAI BANDUNG

Spektrum Industri: Jurnal Ilmiah Pengetahuan dan Penerapan Teknik Industri, 2019
Lean healthcare is one way to identify and minimize waste in every service process at the outpatient installation of Al Islam Bandung Hospital (RSAI). Patients must wait more than 2 hours to get service.
Lisye Fitria, Berliana Annisa Dery, Hendro Prassetiyo   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Development Of A Storage Management Model Based On Lean Warehousing: A Case Study In A Peruvian SME In The Maintenance Services Sector

Proceedings of the Conference on Production Systems and Logistics
The maintenance services sector in Peru faces challenges related to inefficient inventory management and logistics operations, affecting service levels.
Carhuas-Cuyubamba, Grace, Quispe-Alvarez, Ariana, Quiroz-Flores, Carlos, Herberger, David, Hübner, Marco   +4 more
doaj   +1 more source

Application of lean tools in the supply chain of a maintenance environment

South African Journal of Industrial Engineering, 2017
Historically, Lean thinking has limited applications in the maintenance environment (that is, a non-manufacturing environment). This article reports on the Lean tools that can be implemented in the maintenance environment.
Fourie, C. J., Umeh, N. E.
doaj   +1 more source

Lean Service Approach for Consulting Services Company

International Journal of Integrated Engineering, 2019
The service industry sector is one of the livelihoods in Indonesia. This sector has increased from year to year. This study aims to identify and determine the amount of dominant waste in consulting service companies based on the concept of lean service and provide recommendations to minimize the occurrence of dominant waste from the causal factors. The
Elisa Kusrini, Fathia Nisa, Vembri Noor Helia   +2 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source