Results 71 to 80 of about 4,771,009 (283)

Lean thinking in healthcare setting: A Walker-Evant Concept Analysis [PDF]

Journal of Qualitative Research in Health Sciences
Background: This study investigated the application of lean thinking in healthcare settings using Walker and Avant’s eight-step concept analysis method to gain a comprehensive understanding of how lean thinking is implemented in various healthcare ...
Marzieh Helal Birjandi, Hossein Sadeghnezhad, Ahmad Nasiri   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

SimLean : utilising simulation in the implementation of lean in healthcare [PDF]

, 2012
Discrete-event simulation (DES) and lean are approaches that have a similar motivation: improvement of processes and service delivery. Both are being used to help improve the delivery of healthcare, but rarely are they used together.
Worthington, Claire, Radnor, Zoe J., Robinson, Stewart, Burgess, N., Worthington, C., Zoe Radnor (1251978), Robinson, S., Burgess, Nicola, Stewart Robinson (1258410), Radnor, Z. J., Claire Worthington (7200104), Radnor, Z., Nicola Burgess (7200101), Radnor, Zoe Jane   +13 more
core   +2 more sources

Improving clinical access to mental health services in the NHS – the application of Lean thinking [PDF]

, 2013
This paper serves to disseminate findings from implementing Lean in a clinical decision-making service function in a NHS Trust. Operational and performance disparities were identified within the Trust’s service access points, causing inconsistent ...
Bamford, David, Cheng, Siu Yee, Dehe, Benjamin, Duggan, Mary   +3 more
core   +3 more sources

Lean thinking : removing waste and adding value in the public sector - a case study of Cambridgeshire Constabulary, UK [PDF]

, 2009
The idea of lean has provided enormous benefits since its emergence especially in manufacturing where it originated. Through adding value, removing waste and continuous improvement, private organisations have improved their process flow as well as ...
Abubakar Bello, Munir
core   +4 more sources

Lean in the Public Service - an analysis of the literature [PDF]

, 2019
The public services management presents an increasing demand for efficiency, giving more effective results to the citizens. This results-oriented management is a challenge in the context of public services, and the targeting of improvement actions for ...
Bruschi, Mônica, Forcellini, Fernando Antonio   +1 more
core   +1 more source

Lean Six Sigma in the Service Industry [PDF]

, 2012
In light of the increasing importance of the service sector, the objective of this chapter is to discuss whether the business improvement methodology known as Lean Six Sigma is applicable to the service industry as well, and illustrate some case study applications.
openaire   +4 more sources

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

HOSPITAL MANAGEMENT AND NURSING MANAGEMENT IN THE LIGHT OF THE LEAN PHILOSOPHY IN HEALTHCARE

Cogitare Enfermagem, 2019
This article aimed to reflect on hospital management and nursing management based on the Lean Philosophy in Healthcare. It was concluded that hospitals and their most numerous health professionals, the nursing team, may benefit from the application of ...
Thaís Oliveira da Silva, Livia Minuzzi Vieira, Tamires Souza Lemos, Fernando Perdoná Sant’Anna, Roberta Seron Sanches, Maria Regina Martinez   +5 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source