Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Lean principles applied to software development – avoiding waste [PDF]
Under the current economic conditions many organizations strive to continue the trend towards adopting better software development processes, in order to take advantage of the numerous benefits that these can offer.
BRUDARU Paul, Naftanaila Ionel
core
The development and testing of a contextual model for healthcare quality improvement using Lean and the Model for Understanding Success in Quality (MUSIQ) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Quality Systems at Massey University, Palmerston North, New Zealand [PDF]
, 2017 This study developed a new theoretical model of quality improvement (QI) contextual factors, for QI activity undertaken at the healthcare microsystem level.
Wilson, William James
core
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Active Learning Strategies for Teaching Lean Thinking [PDF]
, 2007 Active learning is a method of designing instruction so that classroom students are actively involved in learning concepts and content. Instead of casting students into the role of passive listener, active learning techniques strive to engage learners in
Candido, Jacqueline P. +2 more
core +3 more sources
Lean thinking: using 6S and visual management for efficient adverse event closure. [PDF]
BMJ Open Qual, 2021 Alzahrani Z.
europepmc +1 more source
Performance Improvements through Implementation of Lean Practices: A Study of the U.K. Red Meat Industry [PDF]
'Lean' is an established industrial paradigm with proven track record in various sectors of the industry (Womack & Jones, 1996). World-class Companies such as Toyota (second biggest global car manufacturer), Porsche (most profitable global OEM), Boeing ...
Simons, David, Zokaei, Keivan
core +1 more source
Is good enough 'making do'?: An investigation of inappropriate processing in a small design and build company [PDF]
, 2012 Purpose: The aim was to address behaviour that led to inappropriate processing in a small design and build contracting organisation that employs direct labour. The objective was to reduce process waste and improve the value delivered to clients.
Emmitt, S, Mertia, B, Pasquire, C
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source