Results 51 to 60 of about 299,019 (299)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Lean Thinking: An Essential Mindset

IEEE Engineering Management Review, 2022
Lean thinking is a fundamental mindset to promote societal transformations and prepare society to properly adopt and use Industry 4.0 technologies. These technologies continue to rapidly develop and have started to evolve to Society 5.0 and Industry 5.0.
openaire   +2 more sources

An exploration of knowledge and understanding – the eighth flow [PDF]

, 2013
The argument for understanding Lean construction as a socio-technical field is growing and the need to better consider the role of human beings within construction systems is becoming the dominant factor in project success.
Court, P, Pasquire, C
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Digitalizing sustainability in Pakistan’s textile sector: An investigation of lean digital transformation adoption

International Journal of Engineering Business Management
Rapid digital technology adoption is reshaping manufacturing worldwide, yet Pakistan’s textile industry faces challenges – outdated practices, high innovation costs, and limited lean operations – that constrain competitiveness and sustainability ...
Masooma Zahra, Syed Asif Ali Naqvi, Bilal Hussain, Cosimo Magazzino   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Set-Based Concurrent Engineering process within the LeanPPD environment [PDF]

, 2011
This paper presents a newly defined set-based concurrent engineering process, which the authors believe addresses some of the key challenges faced by engineering enterprises in the 21st century. The main principles of Set-Based Concurrent Engineering (
Al-Ashaab, Ahmed, Doultsinou, Athanasia, Ewers, Paul, Khan, Muhammad, Shehab, Essam, Sulowski, Robert   +5 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Under the Background of “New Normal”, Research on Constructing the Productive and Technical Preparation System Based on Lean Thinking for Locomotives -Take M Company as an Example

MATEC Web of Conferences, 2017
This paper introduces the lean production theory and the application of lean production technology preparation system in related enterprises, put forward own views on a series of problems existing in the preparation of M company's production technology ...
Ma Ming, Lu Tao
doaj   +1 more source

PERANCANGAN PROTOTYPE APLIKASI TERASKILL BERBASIS WEBSITE MENGGUNAKAN PENDEKATAN DESIGN THINKING (STUDI KASUS : PT. MEDIA KREASI ABADI) [PDF]

, 2023
Pembelajaran e-learning merupakan salah satu transformasi paling signifikan yang dilakukan oleh hampir seluruh lembaga pendidikan. E-learning dalam pendapat Khan, merupakan inovasi dari suatu pendekatan yang memusatkan peserta didik dalam pembelajaran ...
Apriliani, Sherin Dwi
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