Results 71 to 80 of about 299,019 (299)

Optimizing efficiency and sustainability in higher education: development and validation of a lean thinking adoption instrument

Frontiers in Education
IntroductionLean Thinking has been applied across various sectors to optimize processes and improve efficiency; however, its implementation in higher education still faces methodological and structural challenges.MethodsThis study developed and validated
Andrés Avilés-Noles, Fabricio Guevara-Viejó, Pedro Javier Fajardo Aguilar, Milton Januario Rueda-Varón, José Divitt Velosa García   +4 more
doaj   +1 more source

Lean-muutostyö Yritys X:lle [PDF]

, 2012
Tämän opinnäytetyön tarkoituksena on selvittää toimeksiannon antaneen yrityksen lean-muutostyön eri vaiheita. Lean-muutostyö tehtiin yrityksen Tuote X:ää alihankintana valmistavaan yksikköön Joensuussa.
Hakulinen, Pekka
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Perampingan efektif kerja pustakawan menurut konsep lean thinking

Khizanah al-Hikmah, 2014
Terbitnya Peraturan Menteri Agama Republik Indonesia Nomor 6 tahun 2013 tentang Organisasi dan Tata Kerja sebagai ortaker baru di lingkungan UIN Syarif Hidayatullah Jakarta mengakibatkan adanya perampingan satuan kerja di lingkungan UIN Syarif ...
Lolytasari Lolytasari
doaj  

Organic produce Value Chain Analysis (OF0344) [PDF]

, 2005
Growth in the Organic food market has been rapid in recent years. According to the soil association, retail sales of organic food are now worth £1.2 billion – an 11% increase on the previous year. Organic Supply Chains have developed to serve different
Simons, David
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Lean Thinking e Lean Project Delivery System

Encontro Nacional de Tecnologia do Ambiente Construído, 2014
In construction, the project area is responsible for the design of Product Development and faces increasing complexity needed to make the product building, having advanced design solutions and managing the interrelationship between different agents. This work is exploratory and analyzes the Lean Thinking (LT) applied to projects as a philosophy that ...
Maria Do Carmo Duarte Freitas, Emilio Lima Nascimento, Sergio Scheer, Lucas Carvalho Nowacki   +3 more
openaire   +1 more source

Introducing the concept of first and last value to aid lean design: learning from social housing projects In Chile [PDF]

, 2011
Value for the customer through efficient production processes is a fundamental principle of Lean. In Lean Construction, Value to customers is largely delivered through project planning and control activities only.
Pasquire, C, Salvatierra-Garrido, J
core   +1 more source