Results 101 to 110 of about 36,022 (270)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Simplicity and the Form of Grammars

open access: yesJournal of Language Modelling, 2021
The goal of theory construction is explanation: for language, theory for particular languages (grammar) and for the faculty of language FoL (the innate endowment for language acquisition). A primitive notion of simplicity of grammars is number of symbols,
Noam Chomsky
doaj  

Network constraints on learnability of probabilistic motor sequences

open access: yes, 2018
Human learners are adept at grasping the complex relationships underlying incoming sequential input. In the present work, we formalize complex relationships as graph structures derived from temporal associations in motor sequences.
Bassett, Danielle S.   +3 more
core   +1 more source

Private List Learnability vs. Online List Learnability

open access: yes
This work explores the connection between differential privacy (DP) and online learning in the context of PAC list learning. In this setting, a $k$-list learner outputs a list of $k$ potential predictions for an instance $x$ and incurs a loss if the true label of $x$ is not included in the list.
Hanneke, Steve   +3 more
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A Systems Approach to Validating Large Language Model Information Extraction: The Learnability Framework Applied to Historical Legal Texts

open access: yesInformation
This paper introduces a learnability framework for validating large language model (LLM) information extraction without ground-truth annotations. Applied to 20,809 Ottoman legal texts, the framework achieves a Learnability Score of 0.891 through multi ...
Ali Çetinkaya
doaj   +1 more source

Trend growth and learning about monetary policy rules [PDF]

open access: yes, 2011
The paper examines the effect of trend productivity growth on the determinacy and learnability of equilibria under alternative monetary policy rules. It shows that under a policy rule that responds to current period inflation and the output gap a higher ...
Tesfaselassie, Mewael F.
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Monetary policy, determinacy, and learnability in a two-block world economy [PDF]

open access: yes
We study how determinacy and learnability of worldwide rational expectations equilibrium may be affected by monetary policy in a simple, two country, New Keynesian framework under both fixed and flexible exchange rates.
Eric Schaling, James B. Bullard
core  

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah   +7 more
wiley   +1 more source

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