Results 61 to 70 of about 132,928 (250)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Efficient packet classification with updatable learned index for online network defense
CybersecurityPacket classification is a cornerstone of network security functions, such as firewalls, access control, and network metering. It involves taking different actions on packets based on security rules to implement these network security functions.
Yuqi Zhang +4 more
doaj +1 more source
An efficient labeled memory system for learned indexes
Fundamental ResearchThe appearance and wide use of memory hardware bring significant changes to the conventional vertical memory hierarchy that fails to handle contentions for shared hardware resources and expensive data movements.
Yuxuan Mo +3 more
doaj +1 more source
Cardiogenic Shock and Lung Injury as a Complication of Defibrillation
Journal of Pediatric Emergency and Intensive Care Medicine, 2017 Local burns, embolism, and arrhythmia are the most common side effects observed after electrical shock treatments. However, systolic function may be rarely affected and pulmonary edema may develop.
Hasan Serdar Kıhtır +6 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2020 Recent advancements in learned index structures propose replacing existing index structures, like B-Trees, with approximate learned models. In this work, we present a unified benchmark that compares well-tuned implementations of three learned index ...
Kipf, A +15 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Lessons learned from linking to 2001 census in Scotland
International Journal of Population Data Science, 2017 Objectives SHELS (Scottish Health and Ethnicity Linkage Study) linked Scotland's 2001 census to various hospital and death data sets with national coverage.
Chris Povey
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
From Family Doctor to Student Preceptor in the Brazilian Unified Health System: Experience Report [PDF]
Revista Brasileira de Educação Médica: Introduction: This article reports the experience of a physician, specialist in Family and Community Medicine, who works in a Basic Health Unit in the southern region of the city of São Paulo, in the Primary Health Care of the Unified Health System ...
Daniel Almeida de Oliveira +1 more
doaj +4 more sources