Results 71 to 80 of about 50,501 (254)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

日本における韓国語教育に関する研究 : 大学の韓国語学習者調査にみる現状と課題 [PDF]

open access: yes, 2017
In this paper, through the questionnaire survey of the Korean language at Okayama Prefectural University, I studied the improvement of Korean language education method and the direction for learner-centered education.
朴 珍希
core   +1 more source

Research Supports Learner-Centered Teaching

open access: yesJournal of the Scholarship of Teaching and Learning, 2013
This is a review of the second edition of Maryellen Weimar's Learner-Centered Teaching: Five Key Changes to Practice (Jossey-Bass, 2013)
Anna Fahraeus
doaj  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Enhancing Feedback Quality at Scale: Leveraging Machine Learning for Learner-Centered Feedback

open access: yesComputers and Education: Artificial Intelligence
In higher education, delivering effective feedback is pivotal for enhancing student learning but remains challenging due to the scale and diversity of student populations. Learner-centered feedback, a robust approach to effective feedback that tailors to
Ahmad Ari Aldino   +4 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The influence of context on science curricula: Observations, conclusions and some recommendations for curriculum development and implementation [PDF]

open access: yes, 2008
The genesis of this project and book was our experiences of teaching science and science education at various levels in developing countries; in the Pacific and the Caribbean.
Coll, Richard K., Taylor, Neil
core   +1 more source

Effect of mixed media visualization on learner perceptions and outcomes [PDF]

open access: yes, 2014
This pilot study examines the effect of mixed media visualization on learner perceptions and outcomes in 3D spatial modeling. The context for this study is a university first year undergraduate interactive media and design course.
Birt, James, Hovorka, Dirk
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Institutionalizing planning, enactment and reflection of daily lessons through appropriate organizational restructuring [PDF]

open access: yes, 2011
Raval, H., McKenney, S., & Pieters, J. (2011). Institutionalizing planning, enactment and reflection of daily lessons through appropriate organizational restructuring.
McKenney, Susan   +2 more
core   +1 more source

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