Results 41 to 50 of about 220 (213)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Workarounds in the Danish Health Sector – from Tacit to Explicit Innovation
Nordic Journal of Working Life Studies, 2018 Drawing on actor-network theory (ANT) and science and technology studies (STS) and on ethnographic research in Denmark, we argue that how health care workers work around technologies can be conceptualized as tacit innovation – that is, practical ...
Katia Dupret, Bjarke Friborg
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Multiple Forms of Professional Agency for (non)crafting of Work Practices in a Hospital Organization
Nordic Journal of Working Life Studies, 2015 In recent working life studies, professional agency is seen as pivotal to the development of work communities and work organizations. This paper addresses professional agency during a practicebased intervention (work conference) in a Finnish hospital ...
Kaija Collin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Wage Inequality Within and Between Occupations
Nordic Journal of Working Life Studies, 2017 Western countries, including Scandinavian nations, have witnessed an increase in wage inequality over the past decades. Recent studies attribute rising wage inequality in the United States and United Kingdom primarily to between-occupation inequality ...
Håvard Helland, Thijs Bol, Ida Drange
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
On Different Tracks? Gender, Professional Strategies, and Early Career Wage Gaps
Nordic Journal of Working Life Studies, 2017 A longstanding notion in labor market theory is that women accommodate family responsibilities in their occupational and job choices. Utilizing a survey of newly graduated highly educated men and women in five occupations in Sweden (n≈2400), the article ...
Anne Grönlund
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Nordic Journal of Working Life Studies, 2016 In-house family ties at workplaces occur in most contexts, and are associated with both advantages and disadvantages. On the basis of 40 interviews with human resource managers at Swedish workplaces, the values and risks of in-house family ties and their
Katarina Haugen, Kerstin Westin
doaj +1 more source