Results 111 to 120 of about 31,003,301 (345)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Approaches to learning and learning values: an investigation of adult learners in Malaysia [PDF]

, 2006
This research was inspired by a pressing question which formed the main aim of the current study--What factors contribute to the differential academic performance of adult learners in the formal setting in Malaysia?
Tan, Po Li
core  

Towards a reconciliation of the 'approaches to learning' and 'critical pedagogy' perspectives in higher education through a focus on academic engagement. [PDF]

, 2005
In this paper, we outline how the literature on phenomenography, specifically Marton and Booth (1997), and the literature that adopts a ‘critical approach’, specifically Friere (1996), can be brought together to help us to understand the barriers that ...
Ashwin, Paul, McLean, Monica
core   +3 more sources

Artificial Intelligence and COVID-19: Deep Learning Approaches for Diagnosis and Treatment

IEEE Access, 2020
COVID-19 outbreak has put the whole world in an unprecedented difficult situation bringing life around the world to a frightening halt and claiming thousands of lives.
M. Jamshidi, A. Lalbakhsh, J. Talla, Z. Peroutka, F. Hadjilooei, Pedram Lalbakhsh, M. Jamshidi, L. La Spada, M. Mirmozafari, Mojgan Dehghani, Asal Sabet, Saeed Roshani, S. Roshani, Nima Bayat-Makou, B. Mohamadzade, Zahra Malek, A. Jamshidi, S. Kiani, Hamed Hashemi‐Dezaki, Wahab Mohyuddin   +19 more
semanticscholar   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Higher Education: Increased and Equitable Access to Quality Learning Opportunities

, 2019
Given that many developing countries seek to increase participation in Higher Education (HE), COL will work with Ministries of Education and HE Institutions to support capacity building including the development and implementation of Open and Distance ...
Commonwealth of Learning
core   +1 more source

Machine learning approaches for crop improvement: Leveraging phenotypic and genotypic big data.

Journal of plant physiology, 2020
Highly efficient and accurate selection of elite genotypes can lead to dramatic shortening of the breeding cycle in major crops relevant for sustaining present demands for food, feed, and fuel.
Hao Tong, Z. Nikoloski
semanticscholar   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

A supervised learning approach to rankability

Computers & Operations Research
12 ...
Nathan McJames, David Malone, Oliver Mason   +2 more
openaire   +5 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source