Results 81 to 90 of about 81,419 (266)

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

UCtracker: A Deep Learning–Based DNA Methylation Model for Noninvasive Diagnosis and Recurrence Surveillance of Urothelial Carcinoma in a Prospective Study

Advanced Science, EarlyView.
We developed UCtracker, a urine DNA methylation–based deep learning model, for noninvasive diagnosis and postoperative surveillance of urothelial carcinoma. UCtracker demonstrates high diagnostic accuracy, robustness at ultralow sequencing depth, early recurrence detection, and dynamic risk‐stratified monitoring of molecular residual disease ...
Shengwei Xiong, Gaojie Li, Yucai Wu, Yuan Liang, Heng Guo, Yu Zhang, Gengyan Xiong, Long Tian, Xin Zhang, Ye Tian, Zhengguo Ji, Bin Guo, Yue Shi, Jian Fan, Zhihua Li, Yanqing Gong, Shiming He, Xuesong Li, Weimin Ci, Liqun Zhou   +19 more
wiley   +1 more source

Infant Motor Competence Predicts Executive Functions in Preschoolers: The Role of Sleep

Behavioral Sciences
The theory of embodied cognition suggests that cognitive development in infancy relies on sensorimotor experiences gained through interaction with the environment.
Chao Liu, Yuzhu Zhang, Xi Liang
doaj   +1 more source

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Learning Work Function via Implicit Reasoning on Electrostatic Potential Landscapes

Advanced Science, EarlyView.
StructPot‐CLR establishes a cross‐modal contrastive learning framework that aligns the crystal structures of 2D materials with plane‐averaged electrostatic potential landscapes for physically informed work‐function prediction. The model achieves an MAE of 0.265 eV and an R2 of 0.902 on the held‐out test set while accurately preserving key morphological
Haoyu Wan, Yue Wu, Tianhao Su, Deng Pan
wiley   +1 more source

Dissociable effects of valence and arousal on different subtypes of old/new effect: Evidence from event-related potentials

Frontiers in Human Neuroscience, 2016
Huifang eXu, Huifang eXu, Qin eZhang, Bingbing eLi, Chunyan eGuo   +4 more
doaj   +1 more source

Anxiety and Social Functioning among People Living with HIV/AIDS (PLWHA) in Pakistan: A Cross-Sectional Study

Nature-Nurture Journal of Psychology
Background: Anxiety is a prevalent psychological comorbidity among people living with HIV/AIDS (PLWHA), contributing to impair social functioning and reduced quality of life.
Dr. Ishrat Yousaf, Muqaddas Asif, Muqqadas Saba, Suleman Shakoor, Ameer Bakhsh Khoso, Nasim Chaudhry   +5 more
doaj   +1 more source

Unveiling the Uncharted Potential of 2D Materials in Li/Na–S Batteries: A Paradigm Shift From Graphene

Advanced Science, EarlyView.
This review explores emerging 2D materials beyond graphene, including graphdiyne, phosphorene, borophene, siloxene, MBene, antimonene, and germanene for Li/Na–S batteries. It analyzes their roles as sulfur hosts, metallic anode protectors, separators, and electrolyte fillers, emphasizing polysulfide suppression, dendrite inhibition, and interfacial ...
Naveen Kumar T. R, Xuebing Zhu, Yao‐Jie Lei, Lei Zhang, Hua Kun Liu, Weihong Lai, Guoxiu Wang, Yun‐Xiao Wang   +7 more
wiley   +1 more source

Mother–Child Synchrony and Behavioral Problems in Chinese Children: A Preliminary fNIRS‐Hyperscanning Study

Brain and Behavior
Introduction Parent–child synchrony, defined as the coordination of biological and behavioral processes during social interactions, serves as a critical predictor of children's psychological health and behavioral outcomes.
Chao Liu, Xi Liang, Xiaoxu Meng, Nanhua Cheng, Shan Lu, Liu Bai, Bingbing Song, Chunming Lu, Zhengyan Wang   +8 more
doaj   +1 more source

Unexpected feedback enhances episodic memory: Exploring signed and unsigned reward prediction errors with EEG

NeuroImage
Reward prediction error (RPE) is crucial for learning and memory, yet its influence on episodic memory remains underexplored. Previous studies have shown two models for the influence of RPE on memory—signed RPE (SRPE) or unsigned RPE (URPE) effects.
Yun Chen, Chunyu Zhao, Rong Liu, Qi Li
doaj   +1 more source