Results 41 to 50 of about 210,555 (261)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Twelve Tips for using Learning Curves in Health Professions Education Research [version 1; peer review: 3 approved]

MedEdPublish, 2023
Learning curves can be used to design, implement, and evaluate educational interventions. Attention to key aspects of the method can improve the fidelity of this representation of learning as well as its suitability for education and research purposes ...
Neva Howard, Kathy Boutis, Roger Edwards, Martin Pusic, Seth Alexander   +4 more
doaj   +1 more source

Learning Curve of Speech Recognition [PDF]

Journal of Digital Imaging, 2013
Speech recognition (SR) speeds patient care processes by reducing report turnaround times. However, concerns have emerged about prolonged training and an added secretarial burden for radiologists. We assessed how much proofing radiologists who have years of experience with SR and radiologists new to SR must perform, and estimated how quickly the new ...
Koivikko Mika P., Kauppinen Tomi A., Koivikko Mika P., Kauppinen Tomi A.   +3 more
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Students’ learning growth in mental addition and subtraction: Results from a learning progress monitoring approach

Frontiers in Psychology, 2022
The purpose of this study was to measure and describe students’ learning development in mental computation of mixed addition and subtraction tasks up to 100.
Sven Anderson, Michael Schurig, Daniel Sommerhoff, Markus Gebhardt   +3 more
doaj   +1 more source

Learning Curve Theory

CoRR, 2021
Recently a number of empirical "universal" scaling law papers have been published, most notably by OpenAI. `Scaling laws' refers to power-law decreases of training or test error w.r.t. more data, larger neural networks, and/or more compute. In this work we focus on scaling w.r.t. data size $n$.
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Assessing the behavior of machine learning methods to predict the activity of antimicrobial peptides

Revista Facultad de Ingeniería, 2016
This study demonstrates the importance of obtaining statistically stable results when using machine learning methods to predict the activity of antimicrobial peptides, due to the cost and complexity of the chemical processes involved in cases where ...
Francy Liliana Camacho, Rodrigo Torres-Sáez, Raúl Ramos-Pollán   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A single-center real-world experience of transoral incisionless fundoplication: Learning curve, proficiency and outcomes

International Journal of Gastrointestinal Intervention
Background : Transoral incisionless fundoplication (TIF) is an effective treatment for gastroesophageal reflux disease. As a technically demanding endoscopic procedure, TIF has a measurable learning curve that may influence procedural performance and ...
Tara Keihanian, Robert Luke Pecha, Margarita Riojas, Kristin Andrews Staggers, Mohamed Othman Othman, Kalpesh Kanu Patel   +5 more
doaj   +1 more source