Results 61 to 70 of about 7,007,541 (299)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Learning Curve? Which One? [PDF]

BAR: Brazilian Administration Review, 2004
Learning curves have been studied for a long time. These studies provided strong support to the hypothesis that, as organizations produce more of a product, unit costs of production decrease at a decreasing rate (see Argote, 1999 for a comprehensive ...
Paulo Prochno
doaj  

Learning Curve Theory

CoRR, 2021
Recently a number of empirical "universal" scaling law papers have been published, most notably by OpenAI. `Scaling laws' refers to power-law decreases of training or test error w.r.t. more data, larger neural networks, and/or more compute. In this work we focus on scaling w.r.t. data size $n$.
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Learning Curves in Open, Laparoscopic, and Robotic Pancreatic Surgery

Annals of Surgery Open, 2022
Objective:. To depict and analyze learning curves for open, laparoscopic, and robotic pancreatoduodenectomy (PD) and distal pancreatectomy (DP). Background:.
P. C. Müller, MD, C. Kuemmerli, MD, A. Cizmic, MD, S. Sinz, MD, P. Probst, MD, MSc, M. de Santibanes, MD, PhD, S. V. Shrikhande, MD, C. Tschuor, MD, PhD, M. Loos, MD, A. Mehrabi, MD, K. Z’graggen, MD, B. P. Müller-Stich, MD, T. Hackert, MD, M. W. Büchler, MD, F. Nickel, MD, MME   +14 more
doaj   +1 more source

Fourier restriction to polynomial curves I: a geometric inequality [PDF]

, 2010
We prove a Fourier restriction result for general polynomial curves in Rd. Measuring the Fourier restriction with respect to the affine arclength measure of the curve, we obtain a universal estimate for the class of all polynomial curves of bounded ...
Wright, James, Wright, J., null Spyridon Dendrinos, null James Wright, Dendrinos, Spyridon, Dendrinos, S.   +5 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Cost Projection of State of the Art Lithium-Ion Batteries for Electric Vehicles Up to 2030

Energies, 2017
The negative impact of the automotive industry on climate change can be tackled by changing from fossil driven vehicles towards battery electric vehicles with no tailpipe emissions.
Gert Berckmans, Maarten Messagie, Jelle Smekens, Noshin Omar, Lieselot Vanhaverbeke, Joeri Van Mierlo   +5 more
doaj   +1 more source

Learning Tone Curves for Local Image Enhancement

IEEE Access, 2022
Image enhancement methods can be formulated as global transformations, local transformations, pixel-wise processing, or a mixture of these operations. Global transformations are limited in enhancing local image regions.
Luxi Zhao, Abdelrahman Abdelhamed, Michael S. Brown   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source