Results 71 to 80 of about 6,149,586 (334)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Money Talks! The Role of Parents’ Discussion of Money for Preschoolers’ Math Knowledge

open access: yesJournal of Numerical Cognition
Children’s participation in cultural, everyday practices and social interactions involving math and money can contribute to the development of their knowledge and skills in these domains.
Shirley Duong   +5 more
doaj   +1 more source

Facilitating learning about academic phraseology: teaching activities for student writers

open access: yesJournal of Learning Development in Higher Education, 2018
Academic Phrasebank is an online, open-access compendium of formulaic phrases for academic writers, created and continuously developed at the University of Manchester.
Mary Davis, John Morley
doaj   +1 more source

E-Learning course development in Moodle [PDF]

open access: yes, 2008
Moodle is a software package for producing internet-based courses and websites. It is an ongoing development project designed to support a social constructionist framework of education. There are several possibilities to create a new curriculum in Moodle.
Herdon, Miklós, Lengyel, Péter
core  

The effects of the design and development of a chemistry curriculum reform on teachers’ professional growth: a case study [PDF]

open access: yes, 2010
A curriculum innovation requires new learning material for students and a preparation program for teachers, in which teacher learning is a key ingredient.
Coenders, Fer   +3 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

The big picture: mining the student data resource to inform learning development provision

open access: yesJournal of Learning Development in Higher Education, 2017
Accurately assessing student needs is a key concern for learning developers in order for provision to have a strong evidence base. Studies investigating student study needs in higher education tend to provide a snapshot in time and are limited to a ...
Elizabeth Tanguay, Peter Hanratty
doaj   +1 more source

Character Development In Mathematics Problem-Based Learning [PDF]

open access: yes, 2011
Concept of learning is an active process to construct meaning as the result relating new ideas on the previous understanding. Therefore, learning mathematics in the classroom is a process to build a deep understanding by the students through activities ...
Sri Hastuti , Noer
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Exploring Ghanaian medical students’ learning experiences during the COVID-19 lockdown: a case study of the University for Development Studies Medical School [version 2; peer review: 2 approved, 1 approved with reservations]

open access: yesF1000Research
Background The COVID-19 pandemic has had a profound impact on health professions education, particularly in developing and middle-income countries. Despite the implementation of alternative educational strategies to facilitate remote learning while ...
Victor Mogre   +4 more
doaj   +1 more source

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