Results 131 to 140 of about 6,561,272 (426)

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

Advanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao, Tianxiang Tang, Bowen Wang, Shengfei He, Yue Zhang, Li Dong, Bo Xu, Ying Liu, Ping Zhu, Rui Guo   +9 more
wiley   +1 more source

AI‐Driven TENGs for Self‐Powered Smart Sensors and Intelligent Devices

Advanced Science, EarlyView.
Triboelectric nanogenerators (TENGs) enable sustainable energy harvesting and self‐powered sensing but face challenges in material optimization, fabrication, and stability. Integrating artificial intelligence (AI) enhances TENG performance through machine learning, improving energy output, adaptability, and predictive maintenance.
Aiswarya Baburaj, Syamini Jayadevan, Akshaya Kumar Aliyana, Naveen Kumar SK, George K Stylios   +4 more
wiley   +1 more source

Prevalence of childhood disability and the characteristics and circumstances of disabled children in the UK : secondary analysis of the Family Resources Survey [PDF]

, 2010
Background: Robust data on the prevalence of childhood disability and the circumstances and characteristics of disabled children is crucial to understanding the relationship between impairment and social disadvantage.
A Mooney, B Beresford, B Beresford, B T, C Blackburn, Clare M Blackburn, D Gordon, D Mont, Department for Education and Skills, Department for Education and Skills Department of Health, Department for Work and Pensions, Department for Work and Pensions, Dobson, Dobson, E Emerson, E Emerson, G Albrecht, H Clarke, H Meltzer, HM Treasury/Department for Education and Skills, J Berthoud, J Bickenbach, J Bradshaw, J Bradshaw, J Mauldon, J Millar, J Read, J Read, J Read, J Van der Lee, Janet M Read, L Clements, L Hoxhallari, M Bajekal, Nick J Spencer, Office for National Statistics, P Cohen, Prime Minister's Strategy Unit, RC Urbano, S Baldwin, S McKay, S Vergeris, T Shakespeare   +42 more
core   +3 more sources

Biomedical Applications of Gadolinium‐Containing Biomaterials: Not Only MRI Contrast Agent

Advanced Science, EarlyView.
This paper summarizes the latest applications and potential mechanisms of the rare earth element gadolinium in biomedical fields, in addition to its traditional application as an MRI contrast agent, including osteogenesis, antimicrobial, antitumor, bioimaging, bioprobes, and so on.
Xingtong Pan, Menglong Hu, Likun Wu, Erfan Wei, Qiyue Zhu, Letian Lv, Xiuyun Xv, Xinyi Dong, Hao Liu, Yunsong Liu   +9 more
wiley   +1 more source

The molecular genetics of RASopathies: An update on novel disease genes and new disorders

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 425-439, December 2022., 2022
Abstract Enhanced signaling through RAS and the mitogen‐associated protein kinase (MAPK) cascade underlies the RASopathies, a family of clinically related disorders affecting development and growth. In RASopathies, increased RAS‐MAPK signaling can result from the upregulated activity of various RAS GTPases, enhanced function of proteins positively ...
Marco Tartaglia, Yoko Aoki, Bruce D. Gelb   +2 more
wiley   +1 more source

Graphomotor and Handwriting Disabilities Rating Scale (GHDRS):towards complex and objective assessment [PDF]

Australian Journalof Learning Difficulties, Routledge, 1-34,2024
Graphomotor and handwriting disabilities (GD and HD, respectively) could significantly reduce children's quality of life. Effective remediation depends on proper diagnosis; however, current approaches to diagnosis and assessment of GD and HD have several limitations and knowledge gaps, e.g.
arxiv   +1 more source

A Dual‐Modal Wearable Pulse Detection System Integrated with Deep Learning for High‐Accuracy and Low‐Power Sleep Apnea Monitoring

Advanced Science, EarlyView.
A dual‐modal wearable pulse detection system is developed for sleep apnea monitoring by integrating a self‐powered PENG and PPG sensor with a biomimetic fingertip structure. Through a two‐stage detection strategy, continuous PPW monitoring and on‐demand PPG detection achieve high‐accuracy sleep apnea recognition while maintaining low power consumption.
Jia Wang, Jiangtao Xue, Yang Zou, Yuxin Ma, Junhan Xu, Yanming Li, Fei Deng, Yiqian Wang, Kai Xing, Zhou Li, Tong Zou   +10 more
wiley   +1 more source

Clinical overview on RASopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 414-424, December 2022., 2022
Abstract RASopathies comprise a group of clinically overlapping developmental disorders caused by genetic variations affecting components or modulators of the RAS‐MAPK signaling cascade, which lead to dysregulation of signal flow through this pathway.
Martin Zenker
wiley   +1 more source

Working Effectively with People with Learning Disabilities [PDF]

, 2001
This brochure on people with learning disabilities and the Americans with Disabilities Act (ADA) is one of a series on human resources practices and workplace accommodations for persons with disabilities edited by Susanne M.
Bruyere, Susanne M, Tominey, Eve Woodman, Tominey, Matthew   +2 more
core   +1 more source

The Dynamic Landscape of 3′‐UTR Alternative Polyadenylation Across Mouse Fetal Development and Anatomy

Advanced Science, EarlyView.
This work maps 3′‐UTR APA across mouse fetal development and tissues, identifying conserved sequence determinants that influence pAS choice. In fetal brain tissues, complex APA dynamics during development are potentially regulated by RBPs like Rbm38, which restrict distal pAS usage.
Qin Wang, Xin Chen, Xiao‐Ou Zhang
wiley   +1 more source