Results 81 to 90 of about 817,680 (305)

Learning Health Systems

Despite enormous efforts at healthcare improvement, major challenges remain in achieving optimal outcomes, safety, cost, and value. This Element introduces the concept of learning health systems, which have been proposed as a possible solution. Though many different variants of the concept exist, they share a learning cycle of capturing data from ...
Foley, Thomas, Horwitz, Leora I.
openaire   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

A Health Promoting Continuous Learning Sustainable Education System

, 2014
This thesis was inspired by a new, evolving vision of a health promoting, continuous learning, education system with an ecological consciousness and focus on sustainability.
Stanton, Colleen Maura
core   +1 more source

Implementation Fidelity of HIV/AIDS Care and Support Services for Orphan and Vulnerable Children in Gondar City, Northwest Ethiopia: A Mixed-Methods Evaluation

Journal of the International Association of Providers of AIDS Care
Objective This study evaluated the implementation fidelity (IF) of HIV/AIDS Care and Support (C&S) services for orphans and vulnerable children (OVC) at the African Network for Prevention and Protection Children against Neglect (ANPPCAN) Project, Gondar ...
Samuel Abebayehu MPH, Endalkachew Mesfin Gebeyehu MPH   +1 more
doaj   +1 more source

The Association of SGLT2i vs DPP4i on Fracture: A Cohort Study in Veterans with Diabetes

American Journal of Medicine Open
Background: Increased bone turnover is associated with use of SGLT2i. Patients with diabetes experience adverse effects on bone metabolism. Our aim was to evaluate if SGLT2i was associated with fractures vs DPP4i as add-on therapy to diabetes regimens ...
Kathryn Snyder, MD, MPH, Katherine Griffin, MPH, Amber Hackstadt, PhD, Amir Javid, PhD, Adriana Hung, MD, MPH, Robert Greevy, PhD, Christianne L. Roumie, MD, MPH   +6 more
doaj   +1 more source

Harnessing Real-World Data to Inform Decision-Making: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS)

Frontiers in Neurology, 2020
Background: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) is the first example of a learning health system in multiple sclerosis (MS).
Ellen M. Mowry, Robert A. Bermel, James R. Williams, Tammie L. S. Benzinger, Carl de Moor, Elizabeth Fisher, Carrie M. Hersh, Megan H. Hyland, Izlem Izbudak, Stephen E. Jones, Bernd C. Kieseier, Hagen H. Kitzler, Lauren Krupp, Yvonne W. Lui, Xavier Montalban, Robert T. Naismith, Jacqueline A. Nicholas, Fabio Pellegrini, Alex Rovira, Maximilian Schulze, Björn Tackenberg, Mar Tintore, Madalina E. Tivarus, Tjalf Ziemssen, Richard A. Rudick   +24 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Fostering Local Health Department and Health System Collaboration Through Case Conferences for At-Risk and Vulnerable Populations

, 2018
In case conferences, health care providers work together to identify and address patients’ complex social and medical needs. Public health nurses from the local health department joined case conference teams at federally qualified health center primary ...
Virginia Caine, Caine, Virginia, Lisa E. Harris, Joshua R. Vest, Watson, Dennis P., Dennis P. Watson, Vest, Joshua R., Harris, Lisa E., Nir Menachemi, Paul Halverson, Menachemi, Nir, Halverson, Paul   +11 more
core   +1 more source

Networked health care: Rethinking value creation in learning health care systems [PDF]

, 2019
Creating better value in health care service today is very challenging. The social pressure to do so is real for every health care system and its leadership. Real benefit has been achieved in manufacturing sector work by the use of “value‐chain” thinking,
Fjeldstad, Øystein D.,, Peter A. Margolis, Paul B. Batalden, Fjeldstad, Øystein D., Batalden, Paul B.,, Julie K. Johnson, Michael Seid, Johnson, Julie K., Seid, Michael, Höglund, Pär, Øystein D. Fjeldstad, Pär Höglund, Fjeldstad, Øystein Devik, Johnson, Julie K.,, Margolis, Peter A.,, Margolis, Peter A., Batalden, Paul B., Seid, Michael,, Höglund, Pär,   +18 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source