Results 71 to 80 of about 817,680 (305)

Learning sites for health systems research: Reflections on five programs in Africa, Asia, and Central America [PDF]

From Wiley via Jisc Publications RouterHistory: received 2024-04-22, rev-recd 2024-11-04, accepted 2024-11-17, epub 2024-12-04Article version: VoRPublication status: PublishedFunder: Foreign Commonwealth and Development Office; Grant(s): PO 8610Funder ...
Witter, Sophie,, van der Merwe, Maria,, Raven, Joanna,, D'Ambruoso, Lucia,, Nzinga, Jacinta, Regmi, Shophika,, Flores, Walter,, Raven, Joanna, Flores, Walter, D'Ambruoso, Lucia, van der Merwe, Maria, Witter, Sophie, Regmi, Shophika, Nzinga, Jacinta,   +13 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The surprising politics of learning health systems

Learning Health Systems
AbstractLearning Health Systems (LHS) are an increasingly common element of health policy reform efforts in a number of jurisdictions. There is little disagreement around the LHS vision, and early adopters provide some development guidance. Despite the attractiveness of the LHS vision, progress on adoption by systems remains slow.
Adalsteinn Brown, Robert J. Reid
openaire   +3 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Identifying requisite learning health system competencies: a scoping review

, 2022
OBJECTIVES: Learning health systems (LHS) integrate knowledge and practice through cycles of continuous quality improvement and learning to increase healthcare quality. LHS have been conceptualised through multiple frameworks and models.
van der Wees, Philip J, McDonald, Paige L, Harwood, Kenneth, Maring, Joyce, Phillips, Jessica   +4 more
core   +1 more source

A qualitative study exploring postpartum patients’ experiences with remote blood pressure monitoring

Pregnancy
Background Hypertensive disorders of pregnancy (HDP) are a leading and often preventable cause of maternal morbidity and mortality. Numerous postpartum remote monitoring programs now exist with varying patient interfaces, functionalities, and levels of ...
Sameepya Thatipelli, Deborah L. Pestka, Kate Honeyfield, Sydney Hansen, Rubina Rizvi, Genevieve B. Melton, Bethany A. Sabol   +6 more
doaj   +1 more source

Evaluation of a Clinical Decision Support Tool to Guide Adoption of the American Heart Association Telemetry Monitoring Practice Standards

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The objectives of this study were to (1) evaluate telemetry use pre‐ and postimplementation of clinical decision support tools to support American Heart Association practice standards for telemetry monitoring and (2) understand the factors ...
Allen Bergstedt, Brian Hilliard, Sarah Alabsi, Michael G. Usher, Maya Peters, James Grace, Genevieve B. Melton, Timothy J. Beebe, Deborah L. Pestka   +8 more
doaj   +1 more source

Leading Learning Health Systems: Strategies Used to Establish and Conduct a Learning Health System

Journal of General Internal Medicine
Abstract Background Learning health systems (LHS) improve patient and provider experiences, population health, and health system performance. LHS leaders develop LHS’ social and scientific infrastructures and align the LHS with host organization’s priorities.
Dawn M. Bravata, Cathy C. Schubert, Amy M. Kilbourne, Scotte R. Hartronft, Ashley L. Schwartzkopf, Jennifer L. Myers, Mindy E. Flanagan, Claire E. Donnelly, Stanley E. Taylor, Mathew J. Reeves, Anthony J. Perkins, Laura E. Myers, Indrakshi Roy, Robert E. Burke, Rachael A. Beard, Marcos Montagnini, Shivani K. Jindal, Greg Arling, Caroline Madrigal, Nicholas A. Rattray   +19 more
openaire   +2 more sources

Learning analysis of health system resilience

Health Policy and Planning
Abstract The emergence of ‘resilience’ as a concept for analysing health systems—especially in low- and middle-income countries—has been trailed by debates on whether ‘resilience’ is a process or an outcome. This debate poses a methodological challenge.
Kyaw Myat Thu, Sarah Bernays, Seye Abimbola   +2 more
openaire   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source