Results 51 to 60 of about 34,884,587 (263)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A qualitative study exploring postpartum patients’ experiences with remote blood pressure monitoring

Pregnancy
Background Hypertensive disorders of pregnancy (HDP) are a leading and often preventable cause of maternal morbidity and mortality. Numerous postpartum remote monitoring programs now exist with varying patient interfaces, functionalities, and levels of ...
Sameepya Thatipelli, Deborah L. Pestka, Kate Honeyfield, Sydney Hansen, Rubina Rizvi, Genevieve B. Melton, Bethany A. Sabol   +6 more
doaj   +1 more source

Evaluation of a Clinical Decision Support Tool to Guide Adoption of the American Heart Association Telemetry Monitoring Practice Standards

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The objectives of this study were to (1) evaluate telemetry use pre‐ and postimplementation of clinical decision support tools to support American Heart Association practice standards for telemetry monitoring and (2) understand the factors ...
Allen Bergstedt, Brian Hilliard, Sarah Alabsi, Michael G. Usher, Maya Peters, James Grace, Genevieve B. Melton, Timothy J. Beebe, Deborah L. Pestka   +8 more
doaj   +1 more source

Geisinger's effort to realize its potential as a learning health system: A progress report

Learning Health Systems, 2021
Objectives In the last two decades, several organizational initiatives have moved Geisinger into closer alignment with the key characteristics of the learning health system (LHS) model.
F. Daniel Davis, Marc S. Williams, Rebecca A. Stametz   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The Association of SGLT2i vs DPP4i on Fracture: A Cohort Study in Veterans with Diabetes

American Journal of Medicine Open
Background: Increased bone turnover is associated with use of SGLT2i. Patients with diabetes experience adverse effects on bone metabolism. Our aim was to evaluate if SGLT2i was associated with fractures vs DPP4i as add-on therapy to diabetes regimens ...
Kathryn Snyder, MD, MPH, Katherine Griffin, MPH, Amber Hackstadt, PhD, Amir Javid, PhD, Adriana Hung, MD, MPH, Robert Greevy, PhD, Christianne L. Roumie, MD, MPH   +6 more
doaj   +1 more source

A Health Promoting Continuous Learning Sustainable Education System [PDF]

, 2014
This thesis was inspired by a new, evolving vision of a health promoting, continuous learning, education system with an ecological consciousness and focus on sustainability.
Stanton, Colleen Maura
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Implementation Fidelity of HIV/AIDS Care and Support Services for Orphan and Vulnerable Children in Gondar City, Northwest Ethiopia: A Mixed-Methods Evaluation

Journal of the International Association of Providers of AIDS Care
Objective This study evaluated the implementation fidelity (IF) of HIV/AIDS Care and Support (C&S) services for orphans and vulnerable children (OVC) at the African Network for Prevention and Protection Children against Neglect (ANPPCAN) Project, Gondar ...
Samuel Abebayehu MPH, Endalkachew Mesfin Gebeyehu MPH   +1 more
doaj   +1 more source