Results 41 to 50 of about 34,884,587 (263)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Developing a highly‐reliable learning health system

Learning Health Systems, 2023
Multiple independent frameworks to support continuous improvement have been proposed to guide healthcare organizations. Two of the most visible are High‐reliability Health care, (Chassin et al., 2013) which is emphasized by The Joint Commission, and ...
Robert El‐Kareh, David A. Brenner, Christopher A. Longhurst   +2 more
doaj   +1 more source

Transforming the future of health together: The Learning Health Systems Consensus Action Plan

, 2018
The Learning Health Community is an emergent global multistakeholder grassroots incipient movement bonded together by a set of consensus Core Values Underlying a National‐Scale Person‐Centered Continuous Learning Health System developed at the 2012 ...
Kate Berry, Marianne Hamilton Lopez, Allen S. Lichter, Humphreys, Darin J., Friedman, Charles P, James M. Walker, Jeffrey Brown, Richard L. Tannen, Rubin, Joshua C., Kush, Rebecca D., Lichter, Allen S., Laura Crawford, Kolodner, Robert M, Friedman, Charles P., Charles P. Friedman, Janet M. Marchibroda, Hamilton Lopez, Marianne, Rubin, Joshua C, Kush, Rebecca D, Silverstein, Jonathan C, Jonathan C. Silverstein, Frank W. Rockhold, Rebecca D. Kush, Crawford, Laura, Rockhold, Frank W., Joshua C. Rubin, Rockhold, Frank W, Marchibroda, Janet M, Marchibroda, Janet M., Brown, Jeffrey, Anderson, W Holt, Kolodner, Robert M., Berry, Kate, Lichter, Allen S, Silverstein, Jonathan C., Robert M. Kolodner, Darin J. Humphreys, Tannen, Richard L, Anderson, W. Holt, Walker, James M., Humphreys, Darin J, W. Holt Anderson, Walker, James M, Tannen, Richard L.   +43 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Gathering speed and countering tensions in the rapid learning health system

Learning Health Systems, 2023
The vision of the learning health system (LHS), conceptualized 15 years ago, is for the rapid generation, use, and spread of high‐quality evidence that yields better health experiences, outcomes, efficiencies, and equity in everyday practice settings ...
Robert J. Reid, Sarah M. Greene
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Reducing hospital acquired pressure injury in a learning health center: Making the case for quality

Learning Health Systems, 2023
Introduction The purpose of this descriptive study is to examine a learning health system (LHS) continuous improvement and learning approach as a case for increased quality, standardized processes, redesigned workflows, and better resource utilization ...
Shea Polancich, Patricia Patrician, Rebecca Miltner, Katherine Meese, Amy Armstrong, Shannon Layton, Ross Vander Noot, Terri Poe, Allyson G. Hall   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The triple helix of clinical, research, and education missions in academic health centers: A qualitative study of diverse stakeholder perspectives

Learning Health Systems, 2021
Introduction Academic health centers are poised to improve health through their clinical, education, and research missions. However, these missions often operate in silos.
Jed D. Gonzalo, Michael Dekhtyar, Kelly J. Caverzagie, Barbara K. Grant, Steven K. Herrine, Abraham M. Nussbaum, Darlene Tad‐y, Earla White, Daniel R. Wolpaw   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source