Results 81 to 90 of about 14,392,939 (341)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Comparison the Application of PBL (Project Based Learning) and PBL (Problem Based Learning) Learning Model on Online Marketing Subjects

open access: yesJPBM (Jurnal Pendidikan Bisnis dan Manajemen), 2017
Purpose of this study are (1) the application of learning PjBL with PBL to improve study results students, (2) assessing the domain affective, cognitive, and psychomotor, (3) the difference study results use the PjBL with PBL to improve study results ...
Agnes Dini Mardani   +2 more
doaj   +1 more source

Evidence of STEM enactment effectiveness in Asian student learning outcomes

open access: yes, 2020
This study used a systematic review and meta-analysis as a method to investigate whether STEM enactment in Asia effectively enhances students’ learning outcomes.
B. Wahono, P. Lin, Chun-Yen Chang
semanticscholar   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Penerapan Model Discovery Learning pada Pembelajaran IPA Materi Tekanan untuk Meningkatkan Hasil Belajar Siswa

open access: yesJurnal Kependidikan, 2019
The purpose of this study was to improve the student learning outcomes of grades VIII.1 SMP Negeri 4 Tanjung in learning science subject matter through the application of Discovery learning models.
Fitriana Fitriana
doaj   +1 more source

Training Medical Student Facilitators of Peer-Assisted Study Sessions Using an Objective Standardized Teaching Exercise

open access: yesMedEdPORTAL, 2020
Introduction Peer-assisted study sessions (P.A.S.S.) are medical student–facilitated small-group sessions that aim to improve students’ knowledge and performance in preclinical courses.
Amber Whitmill   +2 more
doaj   +1 more source

The assessment of complex learning outcomes [PDF]

open access: yes, 2003
The Engineering Professors' Council (EPC) produced an output standard in 2000 containing a setof 26 generic statements of what an engineering graduate should have an ability to tackle. In addition, Higher Education (HE) is concerned with the promotion of
Banks, W.M., Knight, Peter T.
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

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