Results 211 to 220 of about 9,259,807 (266)

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

The dynamics of educational transformation: Empirical insights into how innovation, collaboration, and professional development influence digital resource usage across 81 countries. [PDF]

PLoS One
Yuting L, Binti Ahmad Rashid RA, Xiaoying Z, Cheng C.   +3 more
europepmc   +1 more source

Heuristically Adaptive Diffusion‐Model Evolutionary Strategy

Advanced Science, EarlyView.
Building on the mathematical equivalence between diffusion models and evolutionary algorithms, researchers demonstrate unprecedented control over evolutionary optimization through conditional diffusion. By training diffusion models to associate parameters with specific traits, they can guide evolution toward solutions exhibiting desired behaviors ...
Benedikt Hartl, Yanbo Zhang, Hananel Hazan, Michael Levin   +3 more
wiley   +1 more source

AI in the Classroom: Observing Preclinical Students' Use of ChatGPT During Case-Based Learning at a UK Medical School. [PDF]

Clin Teach
Taylor AWR, Patel FY, Smyth EK, Gay S, Bird T.   +4 more
europepmc   +1 more source

Ten simple rules for building a collaborative coding culture. [PDF]

PLoS Comput Biol
Zuckerman AL, Faber S, Shen K, McIntosh AR, Juavinett AL.   +4 more
europepmc   +1 more source

Urban-rural background disparities and their impact on college students' academic outcomes. [PDF]

Front Psychol
Wang L, Pang L, Yang S, Shui H.
europepmc   +1 more source