Results 91 to 100 of about 34,576 (308)
Clinical Pharmacology &Therapeutics, EarlyView.The minimal anticipated biological effect level (MABEL) approach to first‐in‐human (FIH) dose calculation can lead to long dose‐escalation periods before observing clinical activity. We used a novel ex vivo MABEL approach to calculate the FIH starting dose for forimtamig, a T‐cell bispecific antibody under investigation for the treatment of relapsed ...
Thomas E. Kraft +16 more
wiley +1 more source
, 2023 Despite the reported successes and advantages involving the use of amphiphilic surfactants, most notably TPGS-750-M, to enable a multitude of synthetic transformations to be conducted in water, implementation of this methodology within the pharmaceutical
Niginia, Borlinghaus +9 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Despite developments in supporting the identification and selection of fit‐for‐purpose registries, a translational gap remains between the original purposes of clinically focused registries and their current and future expected use in policymaking. This study aimed to assess the extent to which cancer‐focused registries collect essential data elements ...
Manon C. Wilpshaar +4 more
wiley +1 more source
Neural Correlates of Motor Learning, Transfer of Learning, and Learning to Learn [PDF]
Exercise and Sport Sciences Reviews, 2010 Recent studies on the neural bases of sensorimotor adaptation demonstrate that the cerebellar and striatal thalamocortical pathways contribute to early learning. Transfer of learning involves a reduction in the contribution of early learning networks and increased reliance on the cerebellum.
openaire +2 more sources
Policy Integration for Enabling Environments: Decentralised Water Technologies for Rural Water Reuse
Environmental Policy and Governance, EarlyView.ABSTRACT Water reuse holds significant promise for addressing global water challenges, yet wide scale implementation remains limited. Decentralised water technologies for reuse have been highlighted as a potential aide in the reduction of water challenges, specifically for environments that have typically been considered ‘water rich’, and in rural ...
Elizabeth Lawson, Jaime Amezaga
wiley +1 more source
Environmental Policy and Governance, EarlyView.ABSTRACT Increasing electricity demand from data centres, industrial applications, electric vehicles and domestic heating is creating pressure to develop electricity systems in many parts of the world, but especially in Western countries. In response to challenges such as grid congestion, interconnection queues and climate‐related hazards, network ...
Jussi Valta +3 more
wiley +1 more source
Environmental Policy and Governance, EarlyView.ABSTRACT An emerging consensus calls for transformative climate governance. However, what instigates and sustains transformative pathways remains unclear. This study characterises the existence, quality and structural underpinnings of transformative governance capacities in local government climate change response in Aotearoa New Zealand, applying a ...
Gangadari K. Ranawaka +3 more
wiley +1 more source
Everyday parables: learnings from life
, 1997 Reviewed Book: Taylor, James. Everyday parables: learnings from life.
Riegert, Eduard R., Riegert, Ladona
core
, 2010 The robust economic growth across South East Asia and the significant advances in nano-technologies in the past two decades have resulted in the creation of intelligent urban infrastructures.
Wong, Johnny +2 more
core +1 more source
Environmental Policy and Governance, EarlyView.ABSTRACT In light of the democratic and social‐ecological crises, deliberative minipublics such as citizens' assemblies are increasingly implemented and discussed by scholars as a means for sound decision‐making and to enhance public support for sustainability transformations.
Lea Findeis, Nicolas Jager
wiley +1 more source