Results 31 to 40 of about 1,010,511 (312)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

E-Government Effectiveness and Efficiency in EU-28 and COVID-19

Central European Public Administration Review, 2021
The task of every government, especially during the Covid-19 pandemic, is to provide services and goods for citizens and to maintain economic order. Therefore, the combination of legislation, the judiciary and administration is inevitable.
Sabina Hodžić, Dejan Ravšelj, Dubravka Jurlina Alibegović   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Multiset sparse partial least squares path modeling for high dimensional omics data analysis

BMC Bioinformatics, 2020
Background Recent technological developments have enabled the measurement of a plethora of biomolecular data from various omics domains, and research is ongoing on statistical methods to leverage these omics data to better model and understand biological
Attila Csala, Aeilko H. Zwinderman, Michel H. Hof   +2 more
doaj   +1 more source

A conceptual model for students’ satisfaction with team-based learning using partial least squares structural equation modelling in a faculty of life sciences, in the United Kingdom [PDF]

Journal of Educational Evaluation for Health Professions, 2019
Purpose Students’ satisfaction is an essential element in higher education. This study aimed to identify paths and predictive power of students’ satisfaction during team-based learning (TBL) activities in the faculty of life sciences using partial least ...
Andrea Manfrin, Bugewa Apampa, Prabha Parthasarathy   +2 more
doaj   +1 more source

Topographic Measurements and Statistical Analysis in Static Load Testing of Railway Bridge Piers

Infrastructures, 2023
The aim of the paper is to identify a suitable method for assessing the deformation of structures (buildings, bridges, walls, etc.) by means of topographic measurements of significant targets positioned on the infrastructure under consideration.
Massimiliano Pepe, Domenica Costantino, Vincenzo Saverio Alfio   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Numerical Analysis of Least-Squares Group Finite Element Method for Coupled Burgers' Problem

مجلة بغداد للعلوم, 2021
In this paper, a least squares group finite element method for solving coupled Burgers' problem in   2-D is presented. A fully discrete formulation of least squares finite element method is analyzed, the backward-Euler scheme for the time variable is ...
Najat Jalil Noon
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Sparsity-Enhanced Constrained Least-Squares Spectral Analysis with Greedy-FISTA

Remote Sensing
The utilization of the inversion-based algorithm for spectral decomposition using constrained least-squares spectral analysis (CLSSA) facilitates a time–frequency spectrum with higher temporal and frequency resolution. The conventional CLSSA algorithm is
Guohua Wei, Wubing Deng, Zhenchun Li, Li-Yun Fu   +3 more
doaj   +1 more source