Results 51 to 60 of about 1,732,672 (296)

PLASMA: Partial LeAst Squares for Multiomics Analysis

Cancers, 2023
Background/Objectives: Recent growth in the number and applications of high-throughput “omics” technologies has created a need for better methods to integrate multiomics data. Much progress has been made in developing unsupervised methods, but supervised methods have lagged behind. Methods: Here we present the first algorithm, PLASMA, that can learn to
Kyoko Yamaguchi, Salma Abdelbaky, Lianbo Yu, Christopher C. Oakes, Lynne V. Abruzzo, Kevin R. Coombes   +5 more
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Fitting and Cross-Validating Cox Models to Censored Big Data With Missing Values Using Extensions of Partial Least Squares Regression Models

Frontiers in Big Data, 2021
Fitting Cox models in a big data context -on a massive scale in terms of volume, intensity, and complexity exceeding the capacity of usual analytic tools-is often challenging. If some data are missing, it is even more difficult.
Frédéric Bertrand , Frédéric Bertrand , Myriam Maumy-Bertrand , Myriam Maumy-Bertrand    +3 more
doaj   +1 more source

Use of partial least squares regression to impute SNP genotypes in Italian Cattle breeds [PDF]

, 2013
Background The objective of the present study was to test the ability of the partial least squares regression technique to impute genotypes from low density single nucleotide polymorphisms (SNP) panels i.e. 3K or 7K to a high density panel with 50K SNP.
AJ Chamberlain, APW de Roos, BJ Hayes, BJ Hayes, BJ Hayes, BL Browning, C Dimauro, C Hagger, Corrado Dimauro, D Boichard, D Segelke, DP Berry, G Li, G Moser, Gabriele Marras, GCB Schopen, Giustino Gaspa, H Abdi, HA Mulder, HD Daetwyler, I Medugorac, J Chen, JE Pryce, JM Hickey, K Kizilkaya, KA Weigel, KA Weigel, Massimo Cellesi, Nicolò PP Macciotta, P Ajmone-Marsan, P Scheet, Paolo Ajmone-Marsan, PM VanRaden, R Dassonneville, R Dassonneville, Roberto Steri, T Druet, T Druet, TH Meuwissen, Z Zhang   +39 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Sparse multinomial kernel discriminant analysis (sMKDA) [PDF]

, 2009
Dimensionality reduction via canonical variate analysis (CVA) is important for pattern recognition and has been extended variously to permit more flexibility, e.g. by "kernelizing" the formulation.
Abe, Baudat, Billings, Bo, Cawley, Cawley, Centeno, Chen, Chen, Chen, Chen, Crownover, Duda, Gonzalez-Abril, Hastie, Hastie, Hastie, Hong, Hsu, Kitsuchart Pasupa, Krishnapuram, Li, Liang, Liang, Lu, Mayoraz, Mika, Rifkin, Robert F. Harrison, Schölkopf, Shawe-Taylor, Similä, Suykens, Tipping, Van Gestel, Weston, Xu, Xu, Xu, Yu, Zheng   +40 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Robust Total Least Squares Estimation Method for Uncertain Linear Regression Model

Mathematics, 2023
In data analysis and modeling, least squares and total least squares are both mathematical optimization techniques. It is noteworthy that both the least squares method and the total least squares method are used to deal with precise and random data ...
Hongmei Shi, Xingbo Zhang, Yuzhen Gao, Shuai Wang, Yufu Ning   +4 more
doaj   +1 more source

A Risk Comparison of Ordinary Least Squares vs Ridge Regression [PDF]

, 2013
We compare the risk of ridge regression to a simple variant of ordinary least squares, in which one simply projects the data onto a finite dimensional subspace (as specified by a Principal Component Analysis) and then performs an ordinary (un-regularized)
Dean P. Foster, Gabor Lugosi, Lyle H. Ungar, Paramveer S. Dhillon, Sham M. Kakade   +4 more
core   +3 more sources

Partial Least Squares: A Versatile Tool for the Analysis of High-Dimensional Genomic Data [PDF]

, 2005
Partial Least Squares (PLS) is a highly efficient statistical regression technique that is well suited for the analysis of high-dimensional genomic data.
Boulesteix, Anne-Laure, Strimmer, Korbinian   +1 more
core   +2 more sources