Results 51 to 60 of about 24,488,282 (297)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Solution of the least squares method problem of pairwise comparison matrices [PDF]
, 2008 Pairwise comparison matrix, Least squares approximation, Polynomial system, Homotopy method, Incomplete pairwise comparison matrix,
Bozóki, Sándor, Sándor Bozóki
core +1 more source
, 2010 Recent advances in total least squares approaches for solving various errors-in-variables modeling problems are reviewed, with emphasis on the following generalizations: 1.
Markovsky, Ivan +2 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Robust Total Least Squares Estimation Method for Uncertain Linear Regression Model
Mathematics, 2023 In data analysis and modeling, least squares and total least squares are both mathematical optimization techniques. It is noteworthy that both the least squares method and the total least squares method are used to deal with precise and random data ...
Hongmei Shi +4 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A High-Resolution Spectral Analysis Method Based on Fast Iterative Least Squares Constraints
Applied SciencesThe prediction of reservoir and caprock thickness is important in geological evaluations for site selection for aquifer underground gas storage. Therefore, high-resolution seismic identification of reservoirs and caprocks is crucial. High-resolution time–
Yanyan Ma +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Partial Least Squares Methods for Non-Metric Data [PDF]
, 2009 Partial Least Squares (PLS) methods embrace a suite of data analysis techniques based on algorithms belonging to PLS family. These algorithms consist in various extensions of the Nonlinear estimation by Iterative PArtial Least Squares (NIPALS) algorithm,
Russolillo, Giorgio
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source