Results 61 to 70 of about 24,488,282 (297)

Least-squares methods for identifying biochemical regulatory networks from noisy measurements [PDF]

, 2007
<b>Background</b>: We consider the problem of identifying the dynamic interactions in biochemical networks from noisy experimental data.
Postlethwaite, I., Kwang-Hyun Cho, Kim, Jongrae, Heslop-Harrison, P., Heslop-Harrison, Pat, Postlethwaite, I, Bates, D.G., Cho, Kwang-Hyun, Postlethwaite, Ian, Declan G Bates, Bates, DG, Kim, J, Kim, J., Ian Postlethwaite, Cho, K-H., Jongrae Kim, Pat Heslop-Harrison, Bates, Declan, Heslop-Harrison, P, Postlethwaite Ian, Cho Kwang-Hyun, Bates Declan G, Kim Jongrae, Heslop-Harrison Pat   +23 more
core   +1 more source

On the computation of the structured total least squares estimator

, 2004
A class of structured total least squares problems is considered, in which the extended data matrix is partitioned into blocks and each of the blocks is (block) Toeplitz/Hankel structured, unstructured, or noise free.
Van Huffel, S., Kukush, A., Markovsky, I.   +2 more
core   +1 more source

Algorithms and statistical analysis for linear structured weighted total least squares problem

Geodesy and Geodynamics
Weighted total least squares (WTLS) have been regarded as the standard tool for the errors-in-variables (EIV) model in which all the elements in the observation vector and the coefficient matrix are contaminated with random errors.
Jian Xie, Tianwei Qiu, Cui Zhou, Dongfang Lin, Sichun Long   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Consistency of the structured total least squares estimator in a multivariate errors-in-variables model

, 2005
The structured total least squares estimator, defined via a constrained optimization problem, is a generalization of the total least squares estimator when the data matrix and the applied correction satisfy given structural constraints.
Van Huffel, S., Kukush, A., Markovsky, I.   +2 more
core   +1 more source

Lavender hydrosol analysis using UV spectroscopy data and partial least squares regression

MethodsX
The aim of our work was to estimate the composition of hydrosol produced as a byproduct of lavender steam distillation using UV–Vis spectrophotometry in the 200–600 nm wavelength range through a machine learning algorithm.
Sára Preiner, Bálint Levente Tarcsay, Dóra Pethő, Norbert Miskolczi   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source