Results 41 to 50 of about 24,488,282 (297)

Fitting and Cross-Validating Cox Models to Censored Big Data With Missing Values Using Extensions of Partial Least Squares Regression Models

Frontiers in Big Data, 2021
Fitting Cox models in a big data context -on a massive scale in terms of volume, intensity, and complexity exceeding the capacity of usual analytic tools-is often challenging. If some data are missing, it is even more difficult.
Frédéric Bertrand , Frédéric Bertrand , Myriam Maumy-Bertrand , Myriam Maumy-Bertrand    +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Least squares fitting the three-parameter inverse Weibull density [PDF]

, 2010
The inverse Weibull model was developed by Erto [10]. In practice, the unknown parameters of the appropriate inverse Weibull density are not known and must be estimated from a random sample.
Marušić, Miljenko, Darija Marković, Dragan Jukić, Miljenko Marušić, Marković, Darija, Jukić, Dragan   +5 more
core   +1 more source

Sparsity-Enhanced Constrained Least-Squares Spectral Analysis with Greedy-FISTA

Remote Sensing
The utilization of the inversion-based algorithm for spectral decomposition using constrained least-squares spectral analysis (CLSSA) facilitates a time–frequency spectrum with higher temporal and frequency resolution. The conventional CLSSA algorithm is
Guohua Wei, Wubing Deng, Zhenchun Li, Li-Yun Fu   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Reduced-rank Analysis of the Total Least Squares [PDF]

2019 IEEE 20th International Workshop on Signal Processing Advances in Wireless Communications (SPAWC), 2019
The reduced-rank method exploits the distortion-variance tradeoff to yield superior solutions for classic problems in statistical signal processing such as parameter estimation and filtering. The central idea is to reduce the variance of the solution at the expense of introducing a little distortion.
Kyatsandra G. Nagananda, Pramod P. Khargonekar   +1 more
openaire   +3 more sources

Corticomuscular Activity Modeling by Combining Partial Least Squares and Canonical Correlation Analysis

Journal of Applied Mathematics, 2013
Corticomuscular activity modeling based on multiple data sets such as electroencephalography (EEG) and electromyography (EMG) signals provides a useful tool for understanding human motor control systems. In this paper, we propose modeling corticomuscular
Xun Chen, Aiping Liu, Z. Jane Wang, Hu Peng   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The element-wise weighted total least squares problem

, 2006
A new technique for parameter estimation is considered in a linear measurement error model AX approx B, A = A0 + tilde A, B = B0 + tilde B, with row-wise independent and non-identically distributed measurement errors tilde A, tilde B.
Premoli, P., Van Huffel, S., Markovsky, I., Rastello, M.   +3 more
core   +1 more source

New Constructed EEM Spectra Combined with N-PLS Analysis Approach as an Effective Way to Determine Multiple Target Compounds in Complex Samples

Molecules, 2022
Excitation–emission matrix (EEM) fluorescence spectroscopy has been applied to many fields. In this study, a simple method was proposed to obtain the new constructed three-dimensional (3D) EEM spectra based on the original EEM spectra.
Zeying Li, Na Feng, Xinkang Li, Yuan Lin, Xiangzhi Zhang, Baoqiong Li   +5 more
doaj   +1 more source