Results 41 to 50 of about 2,712,723 (299)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Linear least squares estimation of the first order moving average parameter [PDF]

, 2002
We propose an iterative procedure to minimize the sum of squares function which avoids the nonlinear nature of estimating the first order moving average parameter and provides a closed form of the estimator.
Valdero Mora, Emili
core   +6 more sources

Comparitive Study Between Two Ways Least Squares and Adaptive Regression In Regression linear model [PDF]

المجلة العراقية للعلوم الاحصائية, 2007
In this research, we use the ( ) and ( ) two criterions to compare between the estimators of Adaptive Regression model and the estimators of Ordinary and General Least Squares. We found that, Adaptive Regression estimators are more accurate and efficient
doaj   +1 more source

A New Quantile-Based Approach for LASSO Estimation

Mathematics, 2023
Regularization regression techniques are widely used to overcome a model’s parameter estimation problem in the presence of multicollinearity. Several biased techniques are available in the literature, including ridge, Least Angle Shrinkage Selection ...
Ismail Shah, Hina Naz, Sajid Ali, Amani Almohaimeed, Showkat Ahmad Lone   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Comparison Study Between Two Ways Least Squares and Adaptive Regression In Regression linear model [PDF]

المجلة العراقية للعلوم الاحصائية, 2007
In this research, we use on ( ) and ( ) two criterions to compare between the estimators of Adaptive Regression model and the estimators of Ordinary and General Least Squares, we found that, Adaptive Regression estimator is the best by comparing with ...
doaj   +1 more source

Predictive efficiency of ridge regression estimator [PDF]

Yugoslav Journal of Operations Research, 2017
In this article we have considered the problem of prediction within and outside the sample for actual and average values of the study variables in case of ordinary least squares and ridge regression estimators.
Tiwari Manoj, Sharma Amit
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Panel Data Estimation for Correlated Random Coefficients Models

Econometrics, 2019
This paper considers methods of estimating a static correlated random coefficient model with panel data. We mainly focus on comparing two approaches of estimating unconditional mean of the coefficients for the correlated random coefficients models, the ...
Cheng Hsiao, Qi Li, Zhongwen Liang, Wei Xie   +3 more
doaj   +1 more source