Results 161 to 170 of about 3,602,131 (344)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Women´s Return to Work after First Birth in Sweden during 1980-2000 [PDF]
The goal of this study is to investigate whether and how fast Swedish women returned to work after their first birth and what were the incentives and constraints for their decisions during the latest decades when Sweden was experiencing significant ...
Corman, Diana, Hong, Ying
core
The influence of positive work attitude and emotion on intention to leave among ICT professionals in Malaysia / Safiah Omar [PDF]
, 2016 The disequilibrium growth between the skills supplies and the growth of technologies raise a concern for this study to carry out research in the area of intention to leave among the ICT Professionals in Malaysia.
Omar, Safiah
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
The relation between nurses’ quality of work life with intention to leave their job
Nursing Practice Today, 2017 Background & Aim: Nurses’ intention to leave their job is problematic for health system and the quality of work life is one of the important factors affecting this intention.
Obeidollah Faraji +3 more
doaj
Part-time sick leave as a treatment method for individuals with musculoskeletal disorders [PDF]
There is increasing evidence that staying active is an important part of a recovery process for individuals on sick leave due to musculoskeletal disorders (MSDs). It has been suggested that using part-time sick-leave rather than full-time sick leave will
Andrén, Daniela, Svensson, Mikael
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Nursing OpenAim With the implementation of China's three‐child policy in 2021, the nurse population faces an increase in the number of breastfeeding nurses returning to work after maternity leave.
Xin‐li Wan +2 more
doaj +1 more source