Results 111 to 120 of about 4,646,916 (286)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Home-leaving Decision of Daughters and Sons [PDF]
In spite of relevant differences between countries, a common international pattern emerges: daughters leave parental homes earlier than sons. Drawing upon the European Community Household Panel, we explore the impacts of various factors that affect ...
Maria Concetta Chiuri, Daniela Del Boca
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, 2022 Studien zum Leaving Care, dem Prozess des Übergangs von stationären Settings der Kinder- und Jugendhilfe zur eigenverantwortlichen Lebensführung, setzen im deutschsprachigen Raum erst spät an, etwa um das Jahr 2012. Es erstaunt, dass innerhalb der sozialpädagogischen Forschung eine mit diesem Übergangsprozess einhergehende konstatierte Prekarität lange
openaire +1 more source
Young People's Experience of Participation When Exiting out of Care.
Schweizerische Zeitschrift für Soziale Arbeit, 2020 The aim of this paper is to focus on young people's experiences of participation during the process of transition from placements in out-of-home care independent life.
Ingrid Höjer, Yvonne Sjöblom
doaj
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
International Journal of Child, Youth & Family StudiesCare-leaving literature widely utilizes resilience theory. This is due to an acknowledgment that while young people who grew up in care frequently achieve poorer outcomes during their transition from care to independent adulthood, some do well despite ...
Joyce Hlungwani, Adrian D. van Breda
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
A better future for young people leaving care [PDF]
, 2013 Young people leaving statutory care are at high risk of homelessness. The 2008 White Paper on Homelessness. introduced a 'no exits into homelessness' policy that included young people leaving care, and the National Partnership Agreement on Homelessness ...
Burton, Judith +3 more
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source