Results 101 to 110 of about 4,646,916 (286)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Out of care, into university: raising higher education access and achievement of care leavers [PDF]
, 2015 Around 40,000 children are estimated to require out-of-home care in Australia and this number has risen every year over the past decade (Australian Institute of Health and Welfare, 2014a).
Andrew Harvey +3 more
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Assessing Independent Life Skills of Youth in Child Protection: A MultiInformant Approach
European Journal of Psychology Applied to Legal Context, 2022 Laura García-Alba +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Navigating Independence: Solution-Focused Coaching with Young People Leaving Care
International Journal of Evidence Based Coaching and MentoringThis qualitative study explores how 12 care-experienced young people aged 18 to 21 perceive Solution-Focused Coaching during their transition from residential care.
Ade Adetosoye
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Theories used to explain care-leavers' journey out of care: A scoping review.
PLoS ONEThis study was motivated by Mike Stein's 2006 critique of care-leaving research as reflecting a 'poverty of theory'. A scoping review of care-leaving journal articles was conducted for the nine-year period from 2015 to 2023.
Adrian D van Breda, Sasambal Reuben
doaj +1 more source