Results 81 to 90 of about 389,900 (297)

PREPAREDNESS FOR EMANCIPATION OF YOUTH LEAVING ALTERNATIVE CARE IN SERBIA

open access: yesInternational Journal of Child, Youth & Family Studies, 2018
The process of preparing young people for leaving alternative care is not sufficiently researched in Serbia. In order to define what support is necessary for their successful emancipation, this study of 150 young people in care aims to analyse both their
Anita Burgund Isakov, Jasna Hrnčić
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

The development of care co-ordination services in Scotland: a report to Care Co-ordination Network UK [PDF]

open access: yes, 2008
First paragraph: The modernisation of welfare agenda emphasises the need for flexible and individualised services which are accountable and transparent.
Purves, Richard   +2 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Homelessness and leaving care : the experiences of young adults in Queensland and Victoria, and implications for practice [PDF]

open access: yes, 2014
This research first asks ‘What happens when young people leave state care?’ in respect of Victoria and Queensland and second ‘What are the service support implications of this?’ A number of methods were used to explore these questions including semi ...
Crane, Philip R.   +2 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

The neglected shadow: European perspectives on emotional supports for early school leaving prevention [PDF]

open access: yes, 2011
OECD reports emphasise ten key steps to equity in education, with concrete targets related to low attainment and early school leaving. Such steps, however, neglect the importance of emotional dimensions to early school leaving and the consequent need for
Downes, Paul, Paul Downes
core  

Autonomous home-care nursing staff are more engaged in their work and less likely to consider leaving the healthcare sector: a questionnaire survey. [PDF]

open access: yes, 2015
Background The need for home care is rising in many Western European countries, due to the ageing population and governmental policies to substitute institutional care with home care.
Francke, A.L.   +5 more
core   +1 more source

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