Results 81 to 90 of about 4,646,916 (286)

Employment, education and housing outcomes for care leavers from a children's village in Ghana.

Schweizerische Zeitschrift für Soziale Arbeit, 2020
Each year several young people in Ghana make a transition from residential care to adulthood. However, little is known about the adult lives of care leavers in Ghana.
Kwabena Frimpong-Manso
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

(YOU GOTTA HAVE) FRIENDS: CARE LEAVING, FRIENDSHIPS, AND AGENCY INTERVENTION

International Journal of Child, Youth & Family Studies, 2018
This article is based on a presentation at FICE Austria in 2016 that reported on the findings of a qualitative study that explored the perceptions of friendships held by young people in and formerly in care.
Varda Mann-Feder
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Intersection of Leaving Care and Homelessness: A Literature Overview in a Nordic Welfare State Context

Nordisk Välfärdsforskning
Care leavers are significantly overrepresented among young homeless people, a phenomenon that can be found internationally as well as within the Nordic countries.
Alberte Alsø Dokkedal, Veera Niemi, Freydís Freysteinsdóttir, Anne-Kirstine Mølholt, Mattias Bengtsson, Veronika Paulsen, Eva Dögg Sigurðardóttir   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Professional exhaustion, quality and intentions among family health nurses

Revista Brasileira de Enfermagem
Objective: to analyze how family health nurses assess quality of care; check if they have any intention of leaving their current job and nursing; estimate prevalence of professional exhaustion; and correlate these variables.
Vera Regina Lorenz, Marcos Oliveira Sabino, Heleno Rodrigues Corrêa Filho   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Leaving Care in Africa [PDF]

Emerging Adulthood, 2020
Adrian Du Plessis van Breda, Kwabena Frimpong-Manso   +1 more
openaire   +1 more source

One in seven Swiss physicians has left patient care – results from a national cohort study from 1980–2009

Swiss Medical Weekly, 2019
AIMS OF THE STUDY Physician shortage is problematic, but the percentage of physicians who left patient care in Switzerland is unclear. We set out to describe this percentage and determine whether gender or language region was associated with ...
Sven Streit, Bruno R. da Costa, Sandro Christensen, Kali Tal, Ryan Tandjung, Peter Jüni   +5 more
doaj   +1 more source