Results 71 to 80 of about 4,306,090 (193)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2015 The purpose of this paper is less to answer questions than to ask them, and less to define ‘carers’ than to understand who they are. In particular, its purpose is to ask why the label ‘family carer’ may be rejected by some of them, or by particular ...
Care Alliance Ireland
core +1 more source
(YOU GOTTA HAVE) FRIENDS: CARE LEAVING, FRIENDSHIPS, AND AGENCY INTERVENTION
International Journal of Child, Youth & Family Studies, 2018 This article is based on a presentation at FICE Austria in 2016 that reported on the findings of a qualitative study that explored the perceptions of friendships held by young people in and formerly in care.
Varda Mann-Feder
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Nordisk VälfärdsforskningCare leavers are significantly overrepresented among young homeless people, a phenomenon that can be found internationally as well as within the Nordic countries.
Alberte Alsø Dokkedal +6 more
doaj +1 more source
Swiss Medical Weekly, 2019 AIMS OF THE STUDY Physician shortage is problematic, but the percentage of physicians who left patient care in Switzerland is unclear. We set out to describe this percentage and determine whether gender or language region was associated with ...
Sven Streit +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Professional exhaustion, quality and intentions among family health nurses
Revista Brasileira de EnfermagemObjective: to analyze how family health nurses assess quality of care; check if they have any intention of leaving their current job and nursing; estimate prevalence of professional exhaustion; and correlate these variables.
Vera Regina Lorenz +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source