Results 51 to 60 of about 4,646,916 (286)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Transition care for older people leaving hospital: 2005-06 to 2012-13 [PDF]
, 2014 Examines the outcomes for the 87,000 people who received care under the Transition Care Program from 2005–06 to 2012–13. Summary For many older people, a hospital stay can be accompanied by a decline in functioning.
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Analysis of Home Care Supports Funded by the HSE 2008–2016 [PDF]
, 2016 This paper seeks to summarise the situation of publicly funded home care over the period 2008- 2016. Of particular interest is the overall change to the level of resources being directed to home care in the 2016 HSE Service Plan, in particular the actual
Care Alliance Ireland
core
A Phenomenological Approach to Care Leavers’ Transition to Higher Education [PDF]
, 2012 Previous research conducted in the UK has highlighted issues with the educational experiences of care leavers in general and has suggested that life transitions affect care leavers’ later experiences.
King, Nigel +2 more
core +1 more source
SUPPORT FOR YOUTH LEAVING CARE: A NATIONAL RESEARCH STUDY, INDIA
International Journal of Child, Youth & Family Studies, 2020 This paper is a condensed version of a study entitled “Beyond 18: Leaving Child Care Institutions — A Study of Aftercare Practices in Five States of India”, conducted and published in 2019 by Udayan Care, a charitable organisation, with support from ...
Kiran Modi +5 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
An approach to re-designing leaving care interactions
Scottish Journal of Residential Child Care, 2016 Due to the high instances of young people in care becoming homeless after leaving care, the study I undertook for my PhD in design research explored how an intervention could be co-designed to support young people and leaving care workers (LCWs) to share
Gayle Rice
doaj +1 more source
Leaving Care: Unaccompanied Asylum- Seeking Young Afghans Facing Return
Refuge, 2015 Unaccompanied asylum-seeking children in the United Kingdom approach adulthood knowing that they will be encouraged or even forced to return to their countries of birth.
Kim Robinson, Lucy Williams
doaj +1 more source