Results 91 to 100 of about 4,646,916 (286)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Family factors in early school leaving [PDF]

open access: yes, 2013
Young people who leave school early are at greater risk of experiencing long-term unemployment and slipping into social exclusion as a result. This paper looks at the risk factors associated with young people exiting the education system prematurely,
Elly Robinson, Veronica Meredith
core  

Implementation of Leaving Care Policy: Continuing Care in Scotland

open access: yesChild & Family Social Work
ABSTRACT In Scotland, local authorities have the duty to provide ‘continuing care’ to young people who are cared for in foster, kinship or residential settings (known as ‘out‐of‐home care’ in many regions) on their 16th birthday. This provision allows young people up to the age of 21 to remain in the same setting, with the same carers,
Porter, Robert   +3 more
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Romancing the Carer - Intimate Relationships and Family Caring

open access: yes, 2017
The topic of sexuality and romantic intimacy is not an easy one for many to discuss; in particular is it is often seen as secondary to the difficulties being faced in other aspects of life and in the relationship.
Care Alliance Ireland
core  

Book review: Jo Dixon & Mike Stein (2005). Leaving Care: Throughcare and Aftercare in Scotland. London: Jessica Kingsley

open access: yesScottish Journal of Residential Child Care, 2005
It is good to come across a book about leaving care written in a Scottish context. Dixon and Stein's Leaving Care gives a 'warts and all' look at the experiences of young people leaving public care in three differing authorities in Scotland, referred to ...
Maxwell Smart
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Betroffene wissen am besten, was sie nach dem Heimaustritt benötigen

open access: yes, 2019
Welche Hilfen brauchen Jugendliche, die nach einem Heimaustritt plötzlich selbstverantwortlich im Leben stehen? Im partizipativen Forschungs- und Entwicklungsprojekts "Care Leaver erforschen Leaving Care" wird untersucht, was es an Hilfe bereits gibt ...
Weiss, Claudia
core   +1 more source

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