Results 101 to 110 of about 2,249 (191)

Asthma-COPD Overlap Syndrome : a review of current knowledge and future directions [PDF]

, 2017
Asthma and chronic obstructive pulmonary disease are common diseases both characterised by airflow obstruction. Over recent decades the prevailing belief was that asthma and COPD were distinct diseases that can be easily distinguished and require ...
Johnston, Sebastian Lennox, Mallia, Patrick   +1 more
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Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: results from two phase III, randomized, double-blinded, placebo-controlled trials [PDF]

, 2022
Lebrikizumab, a high-affinity IgG-4 monoclonal antibody targeting interleukin (IL)-13, selectively prevents the formation of the IL-13Ra1/IL-4Ra heterodimer receptor signalling complex.
Blauvelt, Andrew, Chu, Chia-Yu, Gontijo Lima, Renata, Guttman-Yassky, Emma, Liu, Zhuqing T, Pillai, Sreekumar, Seneschal, Julien, Silverberg, Jonathan I, Simpson, Eric, Stein Gold, Linda F, Thaçi, Diamant   +10 more
core   +1 more source

A review of standard pharmacological therapy for adult asthma - Steps 1 to 5 [PDF]

, 2015
The aim of pharmacological therapy for asthma is to improve symptoms and lung function and minimise the risk of asthma attacks. The intensity of treatment is based on the level of asthma control and the potential risk of future deterioration.
Patel, Mitesh Dilipkumar Kantilal, Shaw, Dominick E.   +1 more
core   +2 more sources

Efficacy and safety of lebrikizumab for the treatment of moderate-to-severe atopic dermatitis: a systematic review and meta-analysis

Frontiers in Pharmacology
BackgroundLebrikizumab, an IL-13 immunomodulator, has shown recommendable effectiveness and safety in clinical studies for the treatment of moderate-to-severe atopic dermatitis (AD) in adolescents and adults.ObjectiveTo evaluate the efficacy and safety ...
Jinger Lin, Min Luo, Qianwei Zhuo, Nuo Chen, Haosong Zhang, Yue Han   +5 more
doaj   +1 more source

Immunoglobulin G; structure and functional implications of different subclass modifications in initiation and resolution of allergy. [PDF]

, 2017
IgE and not IgG is usually associated with allergy. IgE lodged on mast cells in skin or gut and basophils in the blood allows for the prolonged duration of allergy through the persistent expression of high affinity IgE receptors.
Amlot P. L., Concha L. B., Delves P. J., Edkins A., Finkelman F. D., Hazenbos W. L., Huizinga T. W., Lessof M. H., Mauro M., McConnell T. H., McMenamin C., Mosmann T. R., Palmeira P., Platts‐Mills T. A., Ren R., Schandane L., Tiseo P. J., Van Der Zee J. S., Yang F.   +18 more
core   +2 more sources

Behandlung von juvenilem bullösem Pemphigoid mit Lebrikizumab [PDF]

J Dtsch Dermatol Ges
Wittenberg M, Solimani F, Dilling A, Snobar R, Ghoreschi K, Klemp M, Kusch K.   +6 more
europepmc   +2 more sources

Allergy in severe asthma [PDF]

, 2017
It is well recognized that atopic sensitisation is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term "Severe Asthma" encompasses a highly heterogeneous group
Bakirtas, Arzu, Bel, Elizabeth, Bjermer, Leif, Custovic, Adnan, DEL GIACCO, STEFANO, Diamant, Zuzana, Hamelmann, Eckard, Heffler, Enrico, Kalayci, Ömer, Saglani, Sejal, Sergejeva, Svetlana, Seys, Sven, Simpson, Angela   +12 more
core   +1 more source

Lebrikizumab improves head/neck/face dermatitis and erythema and does not increase treatment-emergent adverse events of head/neck/face erythema in patients with moderate-to-severe atopic dermatitis

Journal of Dermatological Treatment
Purpose of the study Head, neck (HN), and face involvement in atopic dermatitis (AD) poses a major psychological burden and can be challenging to effectively treat.
Jenny E. Murase, Kilian Eyerich, Raj Chovatiya, H. Chih-ho Hong, Christine Bangert, Lindsay Strowd, Mette Deleuran, Amber Reck Atwater, Maria Jose Rueda, Hany Elmaraghy, Maria Lucia Buziqui Piruzeli, Ignasi Pau-Charles, Fan Emily Yang, Jinglin Zhong, Delphine Staumont-Sallé   +14 more
doaj   +1 more source

Asma [PDF]

, 2014
Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas MonizA asma é um conjunto de condições heterogéneas que resulta na obstrução reversível dos brônquios, e é caracterizada por hiper-reatividade e inflamação das ...
Martins, Henrique Gabriel de Oliveira
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Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye [PDF]

, 2017
To date, ocular antibody therapies for the treatment of retinal diseases rely on injection of the drug into the vitreous chamber of the eye. Given the burden for patients undergoing this procedure, less frequent dosing through the use of long-acting ...
Andersen, Nisana, Corn, Jacob E., Dickmann, Leslie, Dion, Michelle Z., Hass, Philip E., Kelley, Robert F., Loyet, Kelly M., Luoma, Jacob, Maass, Katie F., Mathieu, Mary, Rajagopal, Karthikan, Scheer, Justin M., Shatz, Whitney, Shi, Catherine, Tesar, Devin, van Lookeren Campagne, Menno, Wang, Kathryn, Wyatt, Emily A., Yi, Li   +18 more
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