Results 21 to 30 of about 184,198 (266)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Achievement Goals, Student Engagement, and the Mediatory Role of Autonomy Support in Lecture-Based Courses

open access: yesEducation Sciences, 2023
What makes first-semester students stay engaged in non-mandatory lecture-based courses? This study aims to answer this question by analyzing the relationship between student engagement with autonomy support and achievement goals.
Aida Montenegro, Manuela Schmidt
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Geodetic surveying studies for civil engineering students at Tallinn University of Technology

open access: yesGeodesy and Cartography, 2012
Studies in the Tallinn University of Technology are based on a modular system, where geodetic surveying comprises a self-contained study module in the curricula of all civil engineering specialities.
Nelli Ustinova   +3 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

Komarovich V.L. Lectures on F.M. Dostoevsky read in 1921–1922 in Nizhny Novgorod University [PDF]

open access: yesДостоевский и мировая культура: Филологический журнал, 2018
This is the first publication of a course of lectures about the life and works of F.M. Dostoevsky read in 1921–1922 in Nizhny Novgorod State University by V.L.
Olga A. Bogdanova
doaj   +1 more source

Professor Grigory Antonovich Zakhar'in. Unknown clinical lecture notes

open access: yesConsilium Medicum, 2021
Grigory Antonovich Zakhar'in is the founder of the famous Moscow therapeutic school. He had a special way of lecturing, in which he analyzed clinical cases and demonstrated an example of communication with a patient. The disciples of G.A.
V. V. Fomin, A. S. Panferov
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

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