Results 201 to 210 of about 10,879 (228)
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Insights into the Dissolution Behavior of Ledipasvir-Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions.

Molecular Pharmaceutics, 2019
The generation of a colloidal drug-rich phase by dissolving an amorphous solid dispersion (ASD) is thought to have a positive impact on oral absorption and bioavailability. Thus, understanding which formulations generate these species is important.
Chailu Que   +7 more
semanticscholar   +1 more source

FDA-approved antivirals ledipasvir and daclatasvir downregulate the Src-EPHA2-Akt oncogenic pathway in colorectal and triple-negative breast cancer cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Direct-acting antivirals ledipasvir (LDV) and daclatasvir (DCV) are widely used as part of combination therapies to treat Hepatitis C infections. Here we show that these compounds inhibit the proliferation, invasion, and colony formation of triple ...
Betlem Mezquita   +2 more
semanticscholar   +1 more source

UPLC Estimate of Sofosbuvir and Ledipasvir Utilizing Greenness Tool in Conjunction With an Analytical Quality by Design.

Biomedical chromotography
Ledipasvir in combination with sofosbuvir approved by regulatory bodies used to treat chronic hepatitis C. The present work investigates the design and development of a new, quick, green, and selective UPLC (ultra-performance liquid chromatography ...
Ravinder Bairam   +3 more
semanticscholar   +1 more source

Sofosbuvir plus ribavirin and sofosbuvir plus ledipasvir in patients with genotype 1 or 3 hepatitis C virus and severe renal impairment: a multicentre, phase 2b, non-randomised, open-label study.

The Lancet Gastroenterology and Hepatology, 2020
BACKGROUND There is a medical need for highly effective, safe, and well tolerated treatments for patients infected with hepatitis C virus (HCV) with severe renal impairment.
E. Lawitz   +15 more
semanticscholar   +1 more source

Eco-friendly HPTLC method for simultaneous analysis of sofosbuvir and ledipasvir in biological and pharmaceutical samples: Stability indicating study

Microchemical journal (Print), 2020
Recently, many single-pill combinations are used as a promising choice in hepatitis C treatment. However, this trend made a serious challenge to drug analysts due to difficulty of analysis of two or more drugs simultaneously.
Amira F. El-Yazbi   +4 more
semanticscholar   +1 more source

Electroanalytical investigation and determination of hepatitis C antiviral drug ledipasvir at a non-modified boron-doped diamond electrode

, 2020
This study is about the use of the boron-doped diamond electrode pretreated electrochemically (anodic and subsequent cathodic) in the voltammetric determination of hepatitis C antiviral drug ledipasvir.
Shabnam Allahverdiyeva   +5 more
semanticscholar   +1 more source

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