Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2023 The orally available anti‐hepatitis C virus (HCV) drug simeprevir exhibits nonlinear pharmacokinetics at the clinical doses due to saturation of cytochrome P450 (CYP) 3A4 metabolism and organic anion transporting peptide (OATP) 1B mediated hepatic uptake.
Shinji Nakayama +4 more
doaj +2 more sources
Molecular Mechanisms of Resistance to Direct-Acting Antiviral (DAA) Drugs for the Treatment of Hepatitis C Virus Infections [PDF]
Diagnostics, 2023 Hepatitis C virus (HCV) is a hepatotropic virus that affects millions of human lives worldwide. Direct-acting antiviral (DAA) regimens are the most effective HCV treatment option.
Mohammad Asrar Izhari
doaj +2 more sources
Elongation factor Tu promotes the onset of periodontitis through mediating bacteria adhesion [PDF]
npj Biofilms and MicrobiomesPeriodontitis, a leading cause of adult tooth loss and linked to various systemic diseases, is promoted by subgingival plaque biofilms, with Streptococci as early colonizers responsible for surface adhesion.
Leyi Xiao +15 more
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Anais da Academia Brasileira de Ciências, 2021 Direct-acting antivirals have revolutionized the treatment of chronic hepatitis C. Sofosbuvir and simeprevir are prescribed worldwide. However, there is a scarcity of information regarding their genotoxicity.
CARINA S. LIBRELOTTO +4 more
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Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir
ACS Central Science, 2021 Ho Sing Lo +2 more
exaly +2 more sources
Journal of Education, Health and Sport, 2023 Introduction Cirrhosis is a condition in which the liver becomes fibrotic following damage to the liver and transforms the architecture of the organ into regenerative nodules.
Kamila Abram +9 more
doaj +1 more source
Possibilities of using cepeginterferon alpha-2b in double (cepeginterferon alfa-2b and ribavirin) and triple (simeprevir, cepeginterferon alpha-2b, and ribavirin) antiviral therapy regimens for chronic hepatitis C. A review of clinical trials and experience of everyday clinical practice [PDF]
Терапевтический архив, 2016 Since the incidence of chronic hepatitis C (CHC) increases steadily, the priority of national health care is to provide antiviral therapy (AVT) for the maximum number of patients infected with hepatitis C virus (HCV).
O O Znoyko +5 more
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Viruses, 2015 Hepatitis C virus (HCV) infection is one of the leading causes of end-stage liver disease and the main indication for liver transplantation (LT) in most countries.
Bruno Roche +3 more
doaj +1 more source
The Observed Effect of Gastric Bypass Surgery on Direct-acting Antiviral Treatment: a Case Report
Annals of Hepatology, 2018 Chronic hepatitis C virus (HCV) infection can be cured with treatment using direct-acting antivirals (DAAs). Although these drugs have been widely studied, information about certain special populations is missing.
Elise J. Smolders +4 more
doaj +1 more source
Журнал инфектологии, 2017 The incidence of chronic hepatitis C inRussiais extremely high, that requires an increase the access to effective treatment regimens.The aim of the study is to assess the cost of HCV therapy (genotype 1) of naïve patients without cirrhosis with second ...
A. V. Rudakova +4 more
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