Results 1 to 10 of about 2,653,331 (305)

HCV Genotype Distribution and Clinical Characteristics of HCV Mono-Infected and HCV/HIV Co-Infected Patients in Liangshan Prefecture, Sichuan Province, China

Journal of the International Association of Providers of AIDS Care, 2023
Objective: The present study aimed to characterize the genotype distribution and clinical characteristics of HCV monoinfected and HCV/HIV coinfected patients in the Liangshan Prefecture, Sichuan Province, China.
Bianchuan Cao PhD, Mei Liu BD, Tao Jiang BD, Qinghua Yu BD, Tianru Yuan BD, Ping Ding BD, Xian Zhou BD, Yongmao Huang MD, Yongsheng Zou BD, Fuli Huang PhD   +9 more
doaj   +1 more source

Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate Heterodimeric FokI Nuclease Domains

Viruses, 2021
Persistent hepatitis B virus (HBV) infection remains a serious medical problem worldwide, with an estimated global burden of 257 million carriers. Prophylactic and therapeutic interventions, in the form of a vaccine, immunomodulators, and nucleotide and ...
Tiffany Smith, Prashika Singh, Kay Ole Chmielewski, Kristie Bloom, Toni Cathomen, Patrick Arbuthnot, Abdullah Ely   +6 more
doaj   +1 more source

Advances in designing Adeno-associated viral vectors for development of anti-HBV gene therapeutics

Virology Journal, 2021
Despite the five decades having passed since discovery of the hepatitis B virus (HBV), together with development of an effective anti-HBV vaccine, infection with the virus remains a serious public health problem and results in nearly 900,000 annual ...
Njabulo Mnyandu, Shonisani Wendy Limani, Patrick Arbuthnot, Mohube Betty Maepa   +3 more
doaj   +1 more source

Production, Characterization, and Assessment of Permanently Cationic and Ionizable Lipid Nanoparticles for Use in the Delivery of Self-Amplifying RNA Vaccines

Pharmaceutics, 2023
Africa bears the highest burden of infectious diseases, yet the continent is heavily reliant on First World countries for the development and supply of life-saving vaccines.
Dylan Kairuz, Nazia Samudh, Abdullah Ely, Patrick Arbuthnot, Kristie Bloom   +4 more
doaj   +1 more source

Advances with RNAi-Based Therapy for Hepatitis B Virus Infection

Viruses, 2020
Infection with hepatitis B virus (HBV) remains a global health challenge. Approximately 292 million people worldwide are chronically infected with HBV and the annual mortality from the infection is approaching 900,000.
Fiona van den Berg, Shonisani Wendy Limani, Njabulo Mnyandu, Mohube Betty Maepa, Abdullah Ely, Patrick Arbuthnot   +5 more
doaj   +1 more source

AAV Immunotoxicity: Implications in Anti-HBV Gene Therapy

Microorganisms, 2023
Hepatitis B virus (HBV) has afflicted humankind for decades and there is still no treatment that can clear the infection. The development of recombinant adeno-associated virus (rAAV)-based gene therapy for HBV infection has become important in recent ...
Ridhwaanah Jacobs, Makafui Dennis Dogbey, Njabulo Mnyandu, Keila Neves, Stefan Barth, Patrick Arbuthnot, Mohube Betty Maepa   +6 more
doaj   +1 more source

Retrospective chart review of transplant recipients with cytomegalovirus infection who received maribavir in the Phase 3 SOLSTICE trial: Data at 52 weeks post-maribavir treatment initiation

Antiviral Therapy, 2023
Background Cytomegalovirus (CMV) infection is a frequent complication in haematopoietic cell/solid organ transplant (HCT/SOT) recipients. Previous studies report all-cause mortality rates of 31% and 50% in HCT/SOT recipients post-treatment initiation ...
Marielle Bassel, Dorothy Romanus, Tien Bo, Aimee K Sundberg, Sandra Okala, Ishan Hirji   +5 more
doaj   +1 more source

The transformation of HIV therapy: One pill once a day

Antiviral Therapy, 2022
A co-formulated, one pill once a day antiretroviral regimen (single-tablet regimen), containing efavirenz, emtricitabine, and tenofovir disoproxyl fumarate ( Atripla ), revolutionized the antiretroviral therapy landscape.
Madhu C Choudhary, John W Mellors
doaj   +1 more source

Inhibition of replication of hepatitis B virus using transcriptional repressors that target the viral DNA

BMC Infectious Diseases, 2019
Background Chronic infection with hepatitis B virus (HBV) is a serious global health problem. Persistence of the virus occurs as a result of stability of the replication intermediate comprising covalently closed circular DNA (cccDNA).
Kristie Bloom, Haajira Kaldine, Toni Cathomen, Claudio Mussolino, Abdullah Ely, Patrick Arbuthnot   +5 more
doaj   +1 more source

Inhibition of chikungunya virus replication by N-ω-Chloroacetyl-L-Ornithine in C6/36, Vero cells and human fibroblast BJ

Antiviral Therapy, 2023
Background Polyamines are involved in several cellular processes and inhibiting their synthesis affects chikungunya virus (CHIKV) replication and translation, and, therefore, reduces the quantity of infectious viral particles produced.
Lucero Rojas-Luna, Araceli Posadas-Modragón, Amanda M Avila-Trejo, Verónica Alcántara-Farfán, Lorena I Rodríguez-Páez, José Angel Santiago-Cruz, Marvin O Pastor-Alonso, J Leopoldo Aguilar-Faisal   +7 more
doaj   +1 more source