Results 41 to 50 of about 2,653,331 (305)

A real-world study of the efficacy of a simplified pill count-based strategy for treating HCV/HIV coinfection patients

BMC Infectious Diseases
Background Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections are major public health issues throughout the world. In resource-limited areas, successful treatment of HCV/HIV coinfection frequently faces challenges, particularly ...
Bianchuan Cao, Ying Peng, Mei Liu, Ping Ding, Lingyu Tang, Mingxian Guo, Ling Liu, Cunliang Deng, Gang Wu, Li Zhong, Yongsheng Zou   +10 more
doaj   +1 more source

Lipid Nanoparticle-Encapsulated TALEN-Encoding mRNA Inactivates Hepatitis B Virus Replication in Cultured Cells and Transgenic Mice

Viruses
Chronic infection with the hepatitis B virus (HBV) results in over 1 million deaths annually. Although currently licensed treatments, including pegylated interferon-α and nucleoside/nucleotide analogs, can inhibit viral replication, they rarely eradicate
Tiffany Smith, Prashika Singh, Ridhwaanah Bhana, Dylan Kairuz, Kristie Bloom, Mohube Betty Maepa, Abdullah Ely, Patrick Arbuthnot   +7 more
doaj   +1 more source

Letermovir use to treat complex cytomegalovirus reactivations in two heart transplant recipients

Antiviral Therapy, 2022
Letermovir, an anti-cytomegalovirus (CMV) drug, is recommended as a prophylactic agent in patients at risk of CMV infection/reactivation after allogeneic hematopoietic stem cell transplant.
Aude Boignard, Caroline Augier, Mathilde Kheng, Olivier Epaulard, Raphaele Germi   +4 more
doaj   +1 more source

Triagem da potencial atividade antiviral de peptídeos antimicrobianos e da hemolinfa de ostras [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Biotecnologia.Os produtos naturais constituem uma fonte inesgotável de compostos com atividades farmacológicas promissoras, incluindo ação antiviral.
Gomes, Márcia Cristina Carriel
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

In Vitro Transcribed Artificial Primary MicroRNA for the Inhibition of Hepatitis B Virus Gene Expression in Cultured Cells

Microorganisms
Available interventions for the management of chronic hepatitis B (hepB) exhibit limited efficacy and barriers to vaccination against the hepatitis B virus (HBV) have hampered prophylaxis programmes.
Creanne Shrilall, Patrick Arbuthnot, Abdullah Ely   +2 more
doaj   +1 more source

Antiviral T‐cell therapy

Immunological Reviews, 2014
SummarySerious viral infections are a common cause of morbidity and mortality after allogeneic stem cell transplantation. They occur in the majority of allograft recipients and are fatal in 17–20%. These severe infections may be prolonged or recurrent and add substantially to the cost, both human and financial, of the procedure.
Leen, Ann M., Heslop, Helen E., Brenner, Malcolm K.   +2 more
openaire   +3 more sources

A randomized, controlled trial comparing ganciclovir to ganciclovir plus foscarnet (each at half dose) for preemptive therapy of cytomegalovirus infection in transplant recipients [PDF]

, 2004
Forty-eight patients who provided 2 consecutive blood samples that tested positive for cytomegalovirus DNA by polymerase chain reaction (PCR) were randomized to receive either full-dose ganciclovir ( 5 mg/kg intravenously [iv] twice daily) or half-dose ...
Potter, M, Okwuadi, S., Amooty, G., Nebbia, G, Mattes, F. M., Griffiths, PD, Burroughs, A. K., Burroughs, AK, Grace, SC, Hainsworth, EG, Griffiths, P. D., Sweny, P, Grace, S. C., Amooty, G, Emery, V. C., Walker, AFH, Prentice, G., Sweny, P., Hainsworth, E. G., Geretti, AM, Nebbia, G., Sabin, C, Emery, VC, Sabin, C., Geretti, A. M., Potter, M., Brown, V. S., Okwuadi, S, Brown, VS, Hassan-Walker, A. F., Mattes, FM, Prentice, G   +31 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Long-term inhibition of Hepatitis B virus gene expression by a primary microrna expressing ancestral adeno-associated viral vector

Virology Journal
Current treatments for chronic infection with the hepatitis B virus (HBV) rarely cure carriers from the disease. Previously reported use of serotype 8 adeno-associated viral (AAV8) vectors to deliver expression cassettes encoding anti-HBV artificial ...
Njabulo Ziphezinhle Mnyandu, Shonisani Wendy Limani, Abdullah Ely, Reubina Wadee, Patrick Arbuthnot, Mohube Betty Maepa   +5 more
doaj   +1 more source