Results 21 to 30 of about 2,653,331 (305)

Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. [PDF]

, 2010
Specific differences in signaling and antiviral properties between the different Lambda-interferons, a novel group of interferons composed of IL-28A, IL-28B and IL-29, are currently unknown.
Ralf Bartenschlager, Brand, Stephan, Burkhard Göke, Göke, Burkhard, Artur Kaul, Stephan Brand, Beigel, Florian, Kaul, Artur, Kathrin Zitzmann, Helmut M. Diepolder, Diegelmann, Julia, Diepolder, Helmut M., Christoph J Auernhammer, Bartenschlager, Ralf, Helmut M Diepolder, Christoph J. Auernhammer, Julia Diegelmann, Florian Beigel, Zitzmann, Kathrin, Auernhammer, Christoph J.   +19 more
core   +1 more source

A convenient method to generate and maintain poly(A)-encoding DNA sequences required for in vitro transcription of mRNA

BioTechniques, 2019
Generating mRNA in vitro to encode therapeutic or cell-modifying proteins is rapidly gaining favor. An important factor that determines efficiency of translation from in vitro transcribed mRNA is the length of the 3′ poly(A) sequence.
Patrick Arbuthnot, Abdullah Ely, Kristie Bloom   +2 more
doaj   +1 more source

Resistance levels to non-nucleoside reverse transcriptase inhibitors among pregnant women with recent HIV infection in Malawi

Antiviral Therapy, 2022
Background Information on HIV drug resistance (HIVDR) prevalence in people newly diagnosed with HIV is limited. We implemented a cross-sectional study to estimate HIVDR prevalence among pregnant women recently infected with HIV in Malawi.
George Bello, Matthew Kagoli, Sikhona Chipeta, Andrew Auld, Joy C-W Chang, Joshua R DeVos, Evelyn Kim, Jonathan Mkungudza, Danielle Payne, Michael Eliya, Rose Nyirenda, Andreas Jahn, Taziona Mzumara, Bernard Mvula, Sufia Dadabhai, Ireen Namakhoma, Yusuf Babaye, Amalia Giron, Michael R Jordan, Silvia Bertagnolio, Gabrielle O’Malley, Nellie Wadonda-Kabondo   +21 more
doaj   +1 more source

Design of Effective Primary MicroRNA Mimics With Different Basal Stem Conformations

Molecular Therapy: Nucleic Acids, 2016
Primary microRNA (pri-miRNA) mimics are important mediators of effective gene silencing and are well suited for sustained therapeutic applications. Pri-miRNA mimics are processed in the endogenous miRNA biogenesis pathway, where elements of the secondary
Fiona T van den Berg, John J Rossi, Patrick Arbuthnot, Marc S Weinberg   +3 more
doaj   +1 more source

Antiviral therapy for human rabies

, 2015
Human rabies is virtually always fatal despite numerous attempts at aggressive therapy. Most survivors received one or more doses of rabies vaccine prior to the onset of the disease.
Jackson, Alan C., Appolinario, Camila M. [UNESP]   +1 more
core   +1 more source

JNJ-73763989 pharmacokinetics and safety: Liver-targeted siRNAs against hepatitis B virus, in Japanese and non-Japanese healthy adults, and combined with JNJ-56136379 and a nucleos(t)ide analogue in patients with chronic hepatitis B

Antiviral Therapy, 2022
Background JNJ-73763989 comprises two hepatitis B virus (HBV)-specific, liver-targeted N-galactosamine-conjugated short interfering RNA triggers, JNJ-73763976 and JNJ-73763924.
Ed Gane, Man-Fung Yuen, Thomas N Kakuda, Tetsuro Ogawa, Yasushi Takahashi, Nele Goeyvaerts, Isabelle Lonjon-Domanec, Tamisha Vaughan, Thomas Schluep, James Hamilton, Emmanuel Njumbe Ediage, Vera Hillewaert, Jan Snoeys, Oliver Lenz, Willem Talloen, Michael Biermer   +15 more
doaj   +1 more source

Factors associated with non-adherence to HBV antiviral therapy

, 2017
© 2018 International Medical Press. Background: HBV antiviral therapy has the potential to reduce the burden of HBV-related liver disease by suppressing HBV DNA replication to undetectable levels, reducing the progression of liver fibrosis and reducing ...
Iryna Zablotska-Manos, Lisa Maher, Zablotska-Manos, I, Maher, L, Suzanne Sheppard-Law, Holdaway, S, Sheppard-Law, S, Kermeen, M, Lee, A, George, J, Alice Lee, Susan Holdaway, Amany Zekry, Melissa Kermeen, Zekry, A, Jacob George   +15 more
core   +1 more source

Antiretroviral therapy adherence patterns, virological suppression, and emergence of drug resistance: A nested case–control study from Uganda and South Africa

Antiviral Therapy, 2022
Background Relationships between distinct antiretroviral therapy (ART) adherence patterns and risk of drug resistance are not well understood. Methods We conducted a nested case–control analysis within a longitudinal cohort study of individuals ...
Anisha Tyagi, Yao Tong, Dustin J Rabideau, Zahra Reynolds, Tulio De Oliveira, Richard Lessells, Gideon Amanyire, Catherine Orrell, Stephen Asiimwe, Benjamin Chimukangara, Jennifer Giandhari, Sureshnee Pillay, Jessica E Haberer, Mark J Siedner,   +14 more
doaj   +1 more source

A Critical Evaluation of the Preventive Effect of Antiviral Therapy on the Development of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C or B: A Novel Approach by Using Meta-Regression

, 2014
Background: The extent of the effect of antiviral therapy and its predictors in preventing hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C (CHC) or B (CHB) remain unclear.
鄭安理 ;許駿 ;胡賦強, Shen, Ying-Chun;Hsu, Chiun;Cheng, Chia-Chi;Hu, Fu-Chang;Cheng, Ann-Lii   +1 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source