Results 51 to 60 of about 2,251,925 (277)

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Congenital partial pericardial defect discovered incidentally during surgery for lung cancer: a case report and literature review

BMC Surgery, 2021
Background Congenital pericardial defects are rare congenital anomalies, often asymptomatic and incidentally detected during thoracic surgery. Case presentation A 74-year-old man with primary lung cancer (cT1cN0M0, Stage IA3) underwent thoracoscopic ...
Yoshihito Iijima, Masahito Ishikawa, Shun Iwai, Aika Yamagata, Nozomu Motono, Shigeki Yamagishi, Kiyoshi Koizumi, Hidetaka Uramoto   +7 more
doaj   +1 more source

Thrombus entrapment with left atrial appendage closure to facilitate early cardioversion in tachycardiomyopathy: a case report. [PDF]

BACKGROUND The aetiological spectrum of heart failure with reduced ejection fraction is various. Tachycardiomyopathy is recognized as one of the cause, usually made retrospectively.
Schnegg, Bruno, Primiceri, Livia, Räber, Lorenz, Bruno, Jolie   +3 more
core   +2 more sources

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Discriminating factors excluding patients from a catheter-based left atrial appendage closure and an outcome analysis of non-intervened and intervened patients

Archives of Medical Science, 2020
Introduction The catheter-based left atrial appendage closure (LAAC) has evolved as an alternative to oral anticoagulation (OAC) among non-valvular atrial fibrillation (AF) patients in whom long-term OAC is contraindicated.
Christian Fastner, Claude Jabbour, Michael Behnes, Benjamin Sartorius, Annika Wenke, Ibrahim El-Battrawy, Uzair Ansari, Martin Borggrefe, Ibrahim Akin   +8 more
doaj   +1 more source

Left atrial appendage closure for prevention of cardioembolic events. [PDF]

, 2016
Atrial fibrillation (AF) is the most common atrial arrhythmia, with a prevalence of 1-2% in the general population. It increases with age, affecting approximately 7% of individuals age >65 years and 15-20% of octogenarians.
Glökler, Steffen, Windecker, Stephan, Stephan Windecker, Steffen Gloekler, Bernhard Meier, Meier, Bernhard   +5 more
core   +2 more sources

Longitudinal Echocardiographic Surveillance of Aortic Dilation in a Phenotype‐Enriched Turner Syndrome Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Turner syndrome (TS) is associated with thoracic aortopathy and increased risk for aortic dissection, yet the natural history of aortic dilation is not well understood. We performed a retrospective longitudinal study of individuals with TS who participated in the TS Society of the United States Healthy Heart Project between 2003 and 2023 ...
Dylan Doerner, Matthew R. Johnson, Sara Mansoorshahi, Rakesh Kathiresan, Katelyn Abel, Jonathan G. You, Emilio Quezada, Siddharth K. Prakash   +7 more
wiley   +1 more source

Percutaneous Left Atrial Appendage Closure

, 2017
Chronic oral anticoagulation therapy is the standard therapy for preventing thromboembolic events in patients with atrial fibrillation. However, oral anticoagulation has been associated with an increased risk of bleeding events, and despite the ...
Lluis Asmarats, Josep Rodés-Cabau
core   +1 more source

Beyond wound sealing: A dual‐functional adhesive nanofiber membrane promoting coagulation and osteogenesis in extraction sites

BMEMat, EarlyView.
Inspired by the suction mechanics of octopus suckers, a dual‐layer nanofiber membrane integrates antibacterial protection, strong wet adhesion, and osteogenic support, offering a bioinspired strategy for effective hemostasis and alveolar bone preservation.
Huijing Ma, Liheng Gao, Hao Liang, Wentao Jiang, Junyi Wang, Jiajia Wang, Shuhan Duan, Lingxi Meng, Adilijiang Yimiti, Wenjie Zhang   +9 more
wiley   +1 more source

Double device left atrial appendage closure

, 2015
Aims: Percutaneous left atrial appendage (LAA) occlusion is an alternative to oral anticoagulation for the prevention of stroke in patients with non-valvular atrial fibrillation (NVAF).
Glökler, Steffen, Nietlispach, F., Guerios, E., Khattab, Ahmed, Gloekler, Steffen, Nietlispach, Fabian, Schmid, Michael, Khattab, Ahmed Aziz, Meier, Bernhard, Guérios, Enio E   +9 more
core   +1 more source